Catalogo Articoli (Spogli Riviste)


Elephant herpes virus - a problem for breeding and housing of elephants
Burkhardt, S; Hentschke, J; Weiler, H; Ehlers, B; Ochs, A; Walter, J; Wittstatt, U; Goltenboth, R;
Inst Lebensmittel Arzneimittel & Tierseuchen, D-10557 Berlin, Germany InstLebensmittel Arzneimittel & Tierseuchen Berlin Germany D-10557 many Free Univ Berlin, Inst Vet Pathol, D-1000 Berlin, Germany Free Univ Berlin Berlin Germany D-1000 et Pathol, D-1000 Berlin, Germany Zool Garten Berlin, Berlin, Germany Zool Garten Berlin Berlin GermanyZool Garten Berlin, Berlin, Germany Robert Koch Inst, D-1000 Berlin, Germany Robert Koch Inst Berlin GermanyD-1000 Koch Inst, D-1000 Berlin, Germany
Titolo Testata:
fascicolo: 5, volume: 112, anno: 1999,
pagine: 174 - 179
herpes virus; herpes virus viridae; diagnostics; breeding; PCR; terminase; elephant;
Tipo documento:
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Indirizzi per estratti:
Indirizzo: Burkhardt, S Inst Lebensmittel Arzneimittel & Tierseuchen, Invalidenstr 60, D-10557 Berlin, Germany Inst Lebensmittel Arzneimittel & Tierseuchen Invalidenstr 60 Berlin Germany D-10557
S. Burkhardt et al., "Elephant herpes virus - a problem for breeding and housing of elephants", BERL MUN TI, 112(5), 1999, pp. 174-179


Herpesvirus infections which take a fatal turn on African elephants as well as on Asian elephants seem to occur increasingly not only in the USA but also in European stocks. The endotheliotropic herpesvirus causes a rapidly progressing and severe disease which makes any therapeutical effort unsuccessful and finally results in death of the animal, especially in young Asianelephants. As all attempts to culture the virus failed up to now, molecular biological procedures have to be used more often for diagnostical purposetogether with the common methods of pathology, virology, and electronmicroscopical evaluation. This is a report on the case of 'KIBA', an eleven year old male elephant at the Zoological Garden Berlin, infected with the endotheliotropic elephants herpesvirus. 'KIBA' was born at the Zoo in Houston, Texas, and raised within his herd. Upon arriving in Berlin in November 1997 he adapted to the new premises and climate and new social circumstances without any problems. In June 1998 he already serviced three females of his new herd several times. In August 1998 he died after passing a peracute progression of the disease after residenting in Berlin for only 9 months. The dissection of the animal revealed some evidence on an agent damaging the endothelium. Major signs indicating this agent were bleedings in severalserous membranes, mucosa and on the the right atrium, as well as other parts of the myocardium. Furthermore there have been ulcerations at various localisations of the whale digestive tract. Slightly basophilic intranuclear inclusion bodies have been found histologically in endothelial cells of different organ samples. An examination of altered organ-material by electronmicroscopy made some herpesvirus-like particles visible. A virological investigation first revealed evidence of giant cell formations with solitary basophilic intranuclear inclusion bodies in different cell cultures, however, without any distinct cytopathogenic effect. Supported by molecular biological procedures the infection of 'KIBA' couldbe verified as the elephants herpesvirus. By means of PCR and subsequent sequence analysis a DNA-sequence typical for the elephants herpesvirus couldbe obtained which showed an identity of 97 % with the terminase sequence of the elephant herpesvirus described by American authors. The deduced aminoacid-sequences were 100 % identical. To the terminase of the human cytomegalovirus, the elephant sequence had an identity of 53 % (similarity: 74 %). Based on the cooperation of ILAT, Institute of Veterinary-Pathology/Free University Berlin, Robert-Koch- Institut Berlin, and Zoological Garden Berlin, the cause of 'KIBA's' death could be discovered immediately. Possible implications of this case especially on breeding and keeping elephants are discussed briefly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/08/20 alle ore 17:21:38