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Titolo:
Spatial learning deficit after NMDA receptor blockade and state-dependency
Autore:
Kretschmer, BD; Fink, S;
Indirizzi:
Univ Tubingen, Dept Neuropharmacol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 rmacol, D-72074 Tubingen, Germany
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 4, volume: 10, anno: 1999,
pagine: 423 - 428
SICI:
0955-8810(199907)10:4<423:SLDANR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; LONG-TERM POTENTIATION; NUCLEUS-ACCUMBENS; HIPPOCAMPAL-LESIONS; WORKING MEMORY; BASAL GANGLIA; ACID LESIONS; WATER MAZE; RATS; DOPAMINE;
Keywords:
MK-801; state-dependent learning; state dependency; spatial learning; eight-arm radial maze; NMDA; hippocampus; nucleus accumbens; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Kretschmer, BD Univ Tubingen, Dept Neuropharmacol, Mohistr 54-1, D-72074 Tubingen, Germany Univ Tubingen Mohistr 54-1 Tubingen Germany D-72074 ermany
Citazione:
B.D. Kretschmer e S. Fink, "Spatial learning deficit after NMDA receptor blockade and state-dependency", BEHAV PHARM, 10(4), 1999, pp. 423-428

Abstract

The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) (0.08 and 0.12 mg/kg, i.p.) was used to examine whether spatial memory is learned state dependently. Rats pre-treated with drug or saline were trained for 9 days in an eight-arm radial maze, in which four arms were baited. On the tenth day MK-801-treated rats were injected with salineand one group of saline-treated rats were injected with MK-801 (0.12 mg/kg) while another received saline. Performance of spatial memory was analysedfor state-dependency. Neither rats treated with 0.08 mg/kg nor 0.12 mg/kg of MK-801 for 9 days were impaired in recall of spatial memory under saline. However, MK-801 impaired acquisition of spatial memory, with deficits in working memory and less marked deficits in reference memory. Motor activity(speed) was enhanced at both doses. Thus, learning under NMDA receptor blockade does not necessarily produce a condition that impedes the expression of the learning task under a different condition. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:13:48