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Titolo:
Behavioural effects of glutamate receptor agonists in morphine-dependent rats
Autore:
Dravolina, OA; Medvedev, IO; Bespalov, AY;
Indirizzi:
Pavlov Med Univ, Valdman Inst Pharmacol, Lab Behav Pharmacol, St Petersburg 197089, Russia Pavlov Med Univ St Petersburg Russia 197089 St Petersburg 197089, Russia
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 4, volume: 10, anno: 1999,
pagine: 359 - 366
SICI:
0955-8810(199907)10:4<359:BEOGRA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECIPITATED OPIOID WITHDRAWAL; OXIDE SYNTHASE INHIBITORS; NMDA ANTAGONISTS; NITRIC-OXIDE; LOCUS-COERULEUS; ASPARTATE; STIMULUS; MK-801; TOLERANCE; INCREASES;
Keywords:
naloxone; opioid withdrawal; glutamate receptor agonists; nitric oxide donor; drug discrimination; Y-maze; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bespalov, AY Pavlov Med Univ, Valdman Inst Pharmacol, Lab Behav Pharmacol,6-8 Lev Tolstoy St, St Petersburg 197089, Russia Pavlov Med Univ 6-8 Lev Tolstoy St St Petersburg Russia 197089
Citazione:
O.A. Dravolina et al., "Behavioural effects of glutamate receptor agonists in morphine-dependent rats", BEHAV PHARM, 10(4), 1999, pp. 359-366

Abstract

Glutamate receptors are implicated in the development and expression of drug dependence. Substantial experimental evidence suggests that antagonists acting at the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors attenuate the severity of opioid withdrawal. However, it is less clear whether opioid withdrawal can be potentiated by agonists of glutamate receptors. The present study evaluated the behavioural effects of various agonists of glutamate receptors, as well as a nitric oxide (NO) donor, in morphine dependent rats trained to discriminate 0.1 mg/kg of naloxone from saline. None of the following drugs produced appreciable levels of naloxone-like responding (substitution tests) or potentiated the discriminative stimulus effectsof naloxone: NMDA (3-56 mg/kg), glycine (100-1000 mg/kg), glutamate (1000-3000 mg/kg), kainate (0.53 mg/kg), isosorbide dinitrate (30-300 mg/kg). Nevertheless, expression of some morphine withdrawal-like somatic and behavioural signs ('wet-dog'-like shaking, scream on touch, ptosis, tremor, chewing, weight loss) was facilitated by NMDA glycine, and isosorbide dinitrate. These results suggest that, compared to somatic symptoms, subjective effectsof opioid withdrawal (as reflected by discriminative stimulus effects) arenot mimicked by direct activation of glutamate receptors. (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 02/12/20 alle ore 15:07:11