Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study
Autore:
Kee, F; Amouyel, P; Fumeron, F; Arveiler, D; Cambou, JP; Evans, A; Cambien, F; Fruchart, JC; Ducimetiere, P; Dallongeville, J;
Indirizzi:
Inst Pasteur, INSERM, U508, F-59019 Lille, France Inst Pasteur Lille France F-59019 r, INSERM, U508, F-59019 Lille, France Queens Univ Belfast, Div Epidemiol, Belfast, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland , Antrim, North Ireland Inst Pasteur, Dept Atherosclerose, F-59019 Lille, France Inst Pasteur Lille France F-59019 Atherosclerose, F-59019 Lille, France CHRU Lille, Lille, France CHRU Lille Lille FranceCHRU Lille, Lille, France Fac Xavier Bichat, Lab Nutr Humaine, Paris, France Fac Xavier Bichat Paris France Bichat, Lab Nutr Humaine, Paris, France Fac Med Strasbourg, Lab Epidemiol & Sante Publ, Strasbourg, France Fac MedStrasbourg Strasbourg France l & Sante Publ, Strasbourg, France Fac Med Purpan, Dept Epidemiol, Toulouse, France Fac Med Purpan ToulouseFrance Purpan, Dept Epidemiol, Toulouse, France INSERM SC7, Paris, France INSERM SC7 Paris FranceINSERM SC7, Paris, France INSERM, U325, F-59045 Lille, France INSERM Lille France F-59045INSERM, U325, F-59045 Lille, France Univ Lille 2, Lille, France Univ Lille 2 Lille FranceUniv Lille 2, Lille, France Hop Broussais, INSERM, U258, F-75674 Paris, France Hop Broussais Paris France F-75674 , INSERM, U258, F-75674 Paris, France
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 145, anno: 1999,
pagine: 187 - 195
SICI:
0021-9150(199907)145:1<187:LOABGV>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; FRAGMENT-LENGTH-POLYMORPHISMS; FAMILIAL COMBINED HYPERLIPIDEMIA; APOLIPOPROTEIN-CIII GENE; DNA POLYMORPHISMS; ARTERY DISEASE; CHOLESTEROL CONCENTRATION; LINKAGE DISEQUILIBRIUM; LIPOPROTEIN PARTICLES; PLASMA-LIPOPROTEINS;
Keywords:
lipids; lipoproteins; apolipoprotein C-III; apolipoprotein A-I; apolipoprotein A-IV; myocardial infarction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Dallongeville, J Inst Pasteur, INSERM, U508, 1 Rue Prof Calmette, F-59019 Lille, France Inst Pasteur 1 Rue Prof Calmette Lille France F-59019 ce
Citazione:
F. Kee et al., "Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study", ATHEROSCLER, 145(1), 1999, pp. 187-195

Abstract

The goal of the present study was to compare the allele frequency of four polymorphisms at the apo A-I C-III A-IV cluster gene locus-ApoA-I: XmnI andPstI; ApoC-III: SstI; ApoA-IV: XbaI-between male patients who had had a myocardial infarction (n = 614) and matched controls (n = 764). The association with a number of lipid lipoprotein, apolipoprotein and lipoprotein particle variables was also assessed. Patients and subjects were recruited in Belfast, Lille, Strasbourg and Toulouse in the framework of the ECTIM study. In the control group, the frequencies of the different polymorphic alleles were homogeneous among recruitment centres suggesting the absence of any European North to South gradient for these cluster polymorphisms. There was no evidence for a significant difference in allelic distribution between cases and controls suggesting that apo A-I, C-III, A-IV gene cluster polymorphisms do not explain MI survival in this sample of European men. There was no statistically significant association between apo A-I C-III A-IV cluster gene polymorphisms and lipid, lipoprotein, apolipoprotein, and lipoprotein particle levels. In conclusion, in the ECTIM study, the apo A-I, C-III, A-IV gene cluster polymorphism is associated with neither circulating plasma variables nor MI survival. (C) 1999 Elsevier Science Ireland Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:11:31