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Titolo:
Endothelial cell behavior on vascular prosthetic grafts: Effect of polymerchemistry, surface structure, and surface treatment
Autore:
Marois, Y; Sigot-Luizard, MF; Guidoin, R;
Indirizzi:
Univ Laval, Dept Surg, Expt Surg Lab, Quebec City, PQ G1V 3L5, Canada UnivLaval Quebec City PQ Canada G1V 3L5 Quebec City, PQ G1V 3L5, Canada CHUQ, Inst Biomat Quebec Inc, Quebec City, PQ, Canada CHUQ Quebec City PQCanada st Biomat Quebec Inc, Quebec City, PQ, Canada Univ Technol Compiegne, Dept Genie Biol, F-60206 Compiegne, France Univ Technol Compiegne Compiegne France F-60206 -60206 Compiegne, France
Titolo Testata:
ASAIO JOURNAL
fascicolo: 4, volume: 45, anno: 1999,
pagine: 272 - 280
SICI:
1058-2916(199907/08)45:4<272:ECBOVP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPANDED POLYTETRAFLUOROETHYLENE GRAFTS; ARTERIAL PROSTHESES; FOLLOW-UP; IN-VIVO; PLATELET DEPOSITION; DACRON; INVITRO; BIOCOMPATIBILITY; PATENCY; BYPASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Guidoin, R Univ Laval, Dept Surg, Expt Surg Lab, Room 1701,Serv Bldg, Quebec City, PQG1V 3L5, Canada Univ Laval Room 1701,Serv Bldg Quebec City PQ Canada G1V 3L5 da
Citazione:
Y. Marois et al., "Endothelial cell behavior on vascular prosthetic grafts: Effect of polymerchemistry, surface structure, and surface treatment", ASAIO J, 45(4), 1999, pp. 272-280

Abstract

When implanting any vascular prosthetic grafts, one important goal to ensure long-term patency is achieving complete endothelialization of the luminal surface, a process that has rarely been observed clinically in humans. Seeding vascular grafts with endothelial cells has been seen as an attractiveapproach but has not been clinically convincing. A determining factor may be the type of polymer and surface structure. Using organotypic culture assays, the present investigation studied the effect of different polymers, surface structures, and surface treatments on endothelial cell behavior. The materials tested were polyester (PET), polytetrafluoroethylene (PTFE), polyesterurethane (PESU), and polyetherurethane (PETU) grafts with different surface structures. The surface treatments on the PET grafts included impregnation with cross-linked albumin, collagen, and gelatin, and treatments withfluoropolymer and electrically conducting polypyrrole polymer. Low densitypolyethylene (LDPE) and polydimethylsiloxane (PDMS) sheets (smooth surface, plain wall) were used as controls. After incubation for 7 days at 37 degrees C, cell adhesion and migration on the different polymers and structureswere as follows: woven and knitted PET (high porosity) > PTFE, PESU, PETU hydrophobic (low porosity) > PETU hydrophilic, LDPE, PDMS (no porosity). Cell density results showed no difference between polymers and porous structures and a higher cell density on smooth nonporous surfaces. Compared with the nonimpregnated PET structures, knitted PET treated with albumin, collagen, or gelatin showed slight decreases of cell adhesion. No differences in cell migration and density were reported between any of the PET grafts, except for one polyester graft with a different chemistry than Dacron, which exhibited greater cell migration and lower cell density. Polyester grafts with a fluoropolymer treatment showed lower cell adhesion and migration and higher cell density than the nontreated PET. Finally, the woven PET grafts treated with electrically conducting polypyrrole exhibited contrasting cell behavior depending on the conductivity involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:13:15