Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nefopam and clonidine in the prevention of postanaesthetic shivering
Autore:
Piper, SN; Suttner, SW; Schmidt, CC; Maleck, WH; Kumle, B; Boldt, J;
Indirizzi:
Hosp City Ludwigshafen, Dept Anaesthesiol & Intens Care Med, D-67063 Ludwigshafen, Germany Hosp City Ludwigshafen Ludwigshafen Germany D-67063 udwigshafen, Germany
Titolo Testata:
ANAESTHESIA
fascicolo: 7, volume: 54, anno: 1999,
pagine: 695 - 699
SICI:
0003-2409(199907)54:7<695:NACITP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERAL-ANESTHESIA; DOUBLE-BLIND; HYPOTHERMIC PATIENTS; MEPERIDINE; PETHIDINE; DOXAPRAM;
Keywords:
anaesthesia, recovery; complications, shivering; pharmacology, clonidine, nefopam;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Piper, SN Hosp City Ludwigshafen, Dept Anaesthesiol & Intens Care Med, D-67063 Ludwigshafen, Germany Hosp City Ludwigshafen Ludwigshafen Germany D-67063 n, Germany
Citazione:
S.N. Piper et al., "Nefopam and clonidine in the prevention of postanaesthetic shivering", ANAESTHESIA, 54(7), 1999, pp. 695-699

Abstract

Postanaesthetic shivering affects up to 70% of patients after general anaesthesia, and may be very distressing. Various drugs have been used to treator prevent postanaesthetic shivering, but the ideal one has not yet been found. Sixty patients undergoing elective abdominal or orthopaedic surgery under general anaesthesia were included in a randomised, double-blind study. Patients received clonidine (3 mu g.kg(-1)), nefopam (0.15 mg.kg(-1)) or saline 0.9% as a placebo at the end of surgery, prior to extubation. Nefopamand clonidine significantly reduced the incidence and severity of shivering in comparison with the placebo. The recovery time, between the end of anaesthesia and extubation, was significantly longer in the clonidine-treated patients [13.6 (5.2) min] than in either the nefopam [9.6 (2.8) min] or theplacebo [10.0 (5.4) min] groups. Mean arterial blood pressure and heart rate were significantly lower in the clonidine group compared with both othergroups. Our results suggest that nefopam and clonidine are effective in the prevention of postanaesthetic shivering. However, following clonidine administration the recovery time was prolonged and hypotension was significantly greater than after nefopam.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:59:56