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Titolo:
A non-toxic analogue of a coeliac-activating gliadin peptide: a basis for immunomodulation?
Autore:
Biagi, F; Ellis, HJ; Parnell, NDJ; Shidrawi, RG; Thomas, PD; OReilly, N; Corazza, GR; Ciclitira, PJ;
Indirizzi:
St Thomas Hosp, Rayne Inst, GKT, Gastroenterol Unit, London SE1 7EH, England St Thomas Hosp London England SE1 7EH erol Unit, London SE1 7EH, England Imperial Canc Res Fund, Peptide Synth Lab, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England Univ Aquila, Dept Internal Med, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100 t Internal Med, I-67100 Laquila, Italy
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 7, volume: 13, anno: 1999,
pagine: 945 - 950
SICI:
0269-2813(199907)13:7<945:ANAOAC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-INTESTINAL-MUCOSA; CELIAC-DISEASE; T-CELLS; TISSUE TRANSGLUTAMINASE; ALPHA-GLIADIN; ORGAN-CULTURE; IDENTIFICATION; CHALLENGE; MOLECULE; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ciclitira, PJ St Thomas Hosp, Rayne Inst, GKT, Gastroenterol Unit, LambethPalace Rd, London SE1 7EH, England St Thomas Hosp Lambeth Palace Rd London England SE1 7EH and
Citazione:
F. Biagi et al., "A non-toxic analogue of a coeliac-activating gliadin peptide: a basis for immunomodulation?", ALIM PHARM, 13(7), 1999, pp. 945-950

Abstract

Background: A-gliadin residues 31-49 (peptide A) binds to HLA-DQ2 and is toxic to coeliac small bowel, Analogues of this peptide, which bind to DQ2 molecules but are non-toxic, may be a potential route to inducing tolerance to gliadin in patients with coeliac disease. Methods: Toxicity was investigated with small bowel organ culture in six patients with untreated coeliac disease, four with treated coeliac disease and six controls. Analogue peptides comprised alanine substituted variants of peptide A at L31 (peptide D), P36 (E), P38 (F), P39 (G) and P42 (H). Results: Peptides D and E were toxic in biopsies from some patients. Peptides F, G and H were not toxic. Conclusions: Peptide F, which binds to DQ2 more strongly than peptide A, is not toxic in patients with coeliac disease in-vitro; this could be an initial step towards investigation of the induction of tolerance to gliadin inpatients affected by coeliac disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:23:18