Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Low-dose intravenous azathioprine may be effective in the management of acute fulminant colitis complicating inflammatory bowel disease
Autore:
Casson, DH; Davies, SE; Thomson, MA; Lewis, A; Walker-Smiths, JA; Murch, SH;
Indirizzi:
Royal Free & Univ Coll Sch Med, Univ Dept Paediat Gastroenterol, London NW3 2PF, England Royal Free & Univ Coll Sch Med London England NW3 2PF n NW3 2PF, England Univ Dept Paediat Gastroenterol, Dept Histopathol, London, England Univ Dept Paediat Gastroenterol London England opathol, London, England Univ Dept Surg, London, England Univ Dept Surg London EnglandUniv Dept Surg, London, England
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 7, volume: 13, anno: 1999,
pagine: 891 - 895
SICI:
0269-2813(199907)13:7<891:LIAMBE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROHNS-DISEASE; ULCERATIVE-COLITIS; MEDICAL-MANAGEMENT; LONG-TERM; 6-MERCAPTOPURINE; CYCLOSPORINE; PREDNISOLONE; THERAPY; CHILDREN; ATTACKS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Murch, SH Royal Free & Univ Coll Sch Med, Univ Dept Paediat Gastroenterol,Rowland Hill St, London NW3 2PF, England Royal Free & Univ Coll Sch Med Rowland Hill St London England NW3 2PF
Citazione:
D.H. Casson et al., "Low-dose intravenous azathioprine may be effective in the management of acute fulminant colitis complicating inflammatory bowel disease", ALIM PHARM, 13(7), 1999, pp. 891-895

Abstract

Background: The management of acute fulminant colitis unresponsive to intravenous steroids is usually surgical, However, recent evidence suggests that intravenous administration of azathioprine at very high doses may allow more rapid onset of clinical efficacy, although its use has not previously been reported in the emergency situation. Aim: To report the successful use of intravenous azathioprine in the management of acute fulminant colitis complicating both Crohn's disease and ulcerative colitis,Method: We initially used intravenous azathioprine because of the refusal of the family of the first patient to accept surgery following failure of conventional medical management. Importantly the azathioprine was successfulat the low dose of 3 mg/kg,day, equivalent to standard oral doses, Two subsequent patients demonstrated a similar resolution. All were weaned successfully to oral azathioprine and have remained in long-term endoscopic and histological remission. Conclusion: These preliminary data suggest that low-dose intravenous azathioprine may be helpful adjunct therapy in selected cases of severe fulminant colitis, However, the need for close monitoring and daily surgical assessment remains paramount, and a formal trial of low-dose intravenous azathioprine is required before it may be more widely recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:08:21