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Titolo:
Identification and confirmation of quantitative trait loci regulating alcohol consumption in congenic strains of mice
Autore:
Whatley, VJ; Johnson, TE; Erwin, VG;
Indirizzi:
Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA Univ Colorado, Alcohol Res Ctr, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 Alcohol Res Ctr, Boulder, CO 80309 USA Vet Adm Alcohol Res Ctr, Denver, CO USA Vet Adm Alcohol Res Ctr Denver COUSA dm Alcohol Res Ctr, Denver, CO USA Univ Colorado, Hlth Sci Ctr, Sch Pharm, Denver, CO USA Univ Colorado Denver CO USA ado, Hlth Sci Ctr, Sch Pharm, Denver, CO USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 7, volume: 23, anno: 1999,
pagine: 1262 - 1271
SICI:
0145-6008(199907)23:7<1262:IACOQT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-FOSTERING ANALYSIS; INBRED MOUSE STRAINS; ETHANOL-CONSUMPTION; PREFERENCE; DRINKING; BRAIN; INHERITANCE; PHENOTYPES; DEPENDENCE; SELECTION;
Keywords:
alcohol preference (ALCP); alcohol consumption; congenic strains;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Whatley, VJ Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 net, Boulder, CO 80309 USA
Citazione:
V.J. Whatley et al., "Identification and confirmation of quantitative trait loci regulating alcohol consumption in congenic strains of mice", ALC CLIN EX, 23(7), 1999, pp. 1262-1271

Abstract

Background: C57BL/6 inbred mice prefer alcohol whereas DBA/2 mice avoid it. We describe the construction of congenic strains of nice in which DBA/2 alleles for alcohol avoidance were placed on a C57BL/6 background using phenotypic selection. Methods: Mice were primed to drink 10% v/v ethanol in water for 2 days before a two-bottle choice paradigm. N-2 males who demonstrated an alcohol-avoidance phenotype were backcrossed to B6 females to construct 15 independentlines. Results: Eight of these lines were lost due to failure to breed or absenceof males with an alcohol-avoidance phenotype. The remaining sublines were split to form a total of 21 sublines. In the N-7 and N-9 generations, a genome scan located provisional quantitative hair loci (QTLs) on chromosomes 1, 2, 3, 6, and 9. Progeny testing confirmed QTLs on chromosomes 1 and 2. Conclusions: The QTL on chromosome 2 overlaps the 95% confidence interval of Alcp1 whereas that on chromosome 1 is new and has been called Alcp5. Marker-assisted selection was used in the N-9 and subsequent generations to maintain the congenic lines and produce congenic strains.

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Documento generato il 04/04/20 alle ore 19:54:40