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Titolo:
Correlation of survival time with size of axonal swellings in diffuse axonal injury
Autore:
Wilkinson, AE; Bridges, LR; Sivaloganathan, S;
Indirizzi:
Univ Leeds, Sch Med, Gen Infirm, Div Clin Sci Pathol Sci, Leeds LS2 9JT, WYorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT LS2 9JT, WYorkshire, England
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 2, volume: 98, anno: 1999,
pagine: 197 - 202
SICI:
0001-6322(199908)98:2<197:COSTWS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; TRAUMATIC BRAIN INJURY; CLOSED-HEAD INJURY; NEUROFILAMENT SUBUNITS; BETA-APP; DAMAGE; MARKER;
Keywords:
diffuse axonal injury; head injury; beta-amyloid precursor protein immunohistochemistry; forensic neuropathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Wilkinson, AE Univ Leeds, Sch Med, Gen Infirm, Div Clin Sci Pathol Sci, Algernon Firth Bldg, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Algernon Firth Bldg Leeds W Yorkshire England LS2 9JT
Citazione:
A.E. Wilkinson et al., "Correlation of survival time with size of axonal swellings in diffuse axonal injury", ACT NEUROP, 98(2), 1999, pp. 197-202

Abstract

Widespread damage to axons in the white matter of the brain is a well-recognised consequence of nonmissile head injury. This diffuse axonal injury ischaracterised by a gradual swelling of the axon associated with an accumulation of cellular organelles and proteins. We have investigated the relationship between the size of the swellings of the damaged axon with survival time in postmortem brain tissue. Sixty-six cases of head injury with known length of post-traumatic survival were selected for study, and immunohistochemistry for beta-amyloid precursor protein (beta APP) was carried out. The minimum diameter of the beta APP-immunolabelled damaged axons was measured in micrometers using the IBAS image analysis system. There was a strong, positive and significant relationship between the mean size of axonal swelling and survival time which plateaued at around 85 h post injury. With longersurvival times the situation becomes more complex. beta APP immunolabelling of damaged axons can contribute evidence about trauma and post-injury survival time in the forensic setting but should always be assessed with otherevidence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:05:10