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Titolo:
Risk of premenopausal breast cancer in association with occupational exposure to polycyclic aromatic hydrocarbons and benzene
Autore:
Petralia, SA; Vena, JE; Freudenheim, JL; Dosemeci, M; Michalek, A; Goldberg, MS; Brasure, J; Graham, S;
Indirizzi:
NCI, Occupat Epidemiol Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA20892 ccupat Epidemiol Branch, Bethesda, MD 20892 USA SUNY Buffalo, Sch Med & Biomed Sci, Dept Social & Prevent Med, Buffalo, NY14260 USA SUNY Buffalo Buffalo NY USA 14260 ial & Prevent Med, Buffalo, NY14260 USA Univ Quebec, Inst Armand Frappier, Montreal, PQ H3C 3P8, Canada Univ Quebec Montreal PQ Canada H3C 3P8 pier, Montreal, PQ H3C 3P8, Canada McGill Univ, Dept Epidemiol & Biostat, Dept Occupat Hlth, Montreal, PQ, Canada McGill Univ Montreal PQ Canada , Dept Occupat Hlth, Montreal, PQ, Canada
Titolo Testata:
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
fascicolo: 3, volume: 25, anno: 1999,
pagine: 215 - 221
SICI:
0355-3140(199906)25:3<215:ROPBCI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE-SMOKING; ORGANIC-SOLVENTS; WORKERS; MORTALITY; COHORT; WOMEN; HYPOTHESIS; MATRIX; TISSUE; DAMAGE;
Keywords:
benzene; breast cancer; estrogen receptor; occupational exposures; polycyclic aromatic hydrocarcarbons; women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Petralia, SA NCI, Occupat Epidemiol Branch, Execut Plaza S,Rm 8110,6120 Execut Blvd, Bethesda, MD 20892 USA NCI Execut Plaza S,Rm 8110,6120 Execut Blvd Bethesda MD USA 20892
Citazione:
S.A. Petralia et al., "Risk of premenopausal breast cancer in association with occupational exposure to polycyclic aromatic hydrocarbons and benzene", SC J WORK E, 25(3), 1999, pp. 215-221

Abstract

Objectives This study examined the relationship between risk of premenopausal breast cancer and occupational exposure to benzene and polycyclic aromatic hydrocarbons (PAH) and whether the proposed relationship between PAH and breast cancer differed by tumor estrogen receptor (ER) status. Methods In a case-referent study of premenopausal breast cancer, occupational histories and other information were obtained through interviews, and job-exposure matrices were used to assess exposure to PAH and benzene. Results A dose-response relationship for the probability of exposure to benzene [low: odds ratio (OR) 1.64, 95% confidence interval(95% CI) 0.64-4.21;high: OR 1.95, 95% CI 1.14-3.33) and to PAH (low: OR 1.56, 95% CI 0.78-3.12; high: OR 2.40, 95% CI 0.96-6.01). Risk increased with duration of exposure to benzene, but not to PAH. A dose-response relationship was not evidentfor the intensity of exposure to benzene or to PAH. When analyses were stratified by tumor ER status, PAH exposure was related to a greater increase in the risk of ER-positive (OR 2.27, 95% CI 1.14-4.54) than ER-negative (OR1.12, 95% CI 0.47-2.64) breast cancer. Risk of ER-positive, but not ER-negative, tumors increased with the probability of exposure to PAH. Conclusions The findings suggest an association between risk and occupational exposure to benzene. Although it was difficult to study PAH independently of benzene, there was some suggestion of an association between PAH exposure and ER-positive tumors. These data should be interpreted with caution because of the limitations of this study, including low-response rates and small numbers of exposed persons.

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Documento generato il 30/05/20 alle ore 15:02:11