Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF CORTICOSTEROIDS ON RABBIT CORNEAL KERATOCYTES AFTER PHOTOREFRACTIVE KERATECTOMY
Autore:
YOU XK; BERGMANSON JPG; ZHENG XM; MACKENZIE IC; BOLTZ RL; AQUAVELLA JV;
Indirizzi:
UNIV HOUSTON,COLL OPTOMETRY HOUSTON TX 77204 UNIV HOUSTON,COLL OPTOMETRY HOUSTON TX 77204 UNIV TEXAS,INST DENT SCI HOUSTON TX 00000 UNIV ROCHESTER,SCH MED ROCHESTER NY 00000
Titolo Testata:
Journal of refractive surgery
fascicolo: 6, volume: 11, anno: 1995,
pagine: 460 - 467
SICI:
1081-597X(1995)11:6<460:EOCORC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCIMER LASER; PHOTOABLATION; REPAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
X.K. You et al., "EFFECT OF CORTICOSTEROIDS ON RABBIT CORNEAL KERATOCYTES AFTER PHOTOREFRACTIVE KERATECTOMY", Journal of refractive surgery, 11(6), 1995, pp. 460-467

Abstract

BACKGROUND: To determine the corticosteroid effect on the activity and repopulation of keratocytes after photorefractive keratectomy (PRK). METHODS: A 193-nm excimer laser (VISX Twenty/Twenty) created a central ablation depth of 22 mu m (diameter: 5 mm) on 22 corneas of 16 albino rabbits. Two ablated eyes were examined 6 hours following PRK. Twelve eyes received no postoperative corticosteroids and eight were treated with topical fluoromethalone for 3 months. Corneas were examined 1, 3, 6, and 12 months after PRK by immunofluorescence and transmission electron microscopy. RESULTS: Corticosteroids reduced haze (p=0.02), but all corneas (treated or untreated) cleared 6 months after PRK. Keratocytes were absent from the anterior 100 mu m of the stroma 6 hours after PRK. However, the number acid activity of keratocytes were significantly greater in this area in untreated corneas at 1 month and then gradually decreased. By 6 and 12 months, the number of keratocytes approached controls, Treated corneas had fewer keratocytes than either controls or untreated eyes (p<0.01) and by 3 months, a subepithelial acellular zone of 30 to 50 mu m thickness appeared and persisted until at least 12 months after PRK. CONCLUSIONS: Corticosteroids have a transient effect in reducing haze and seem to inhibit keratocyte movement, leading to an acellular subepithelial region beneath the ablated area.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 10:00:43