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Titolo:
Clinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients
Autore:
Tang, S; Chan, TM; Cheng, IKP; Lai, KN;
Indirizzi:
Univ Hong Kong, Queen Mary Hosp, Dept Med, Div Nephrol, Hong Kong, Hong Kong Univ Hong Kong Hong Kong Hong Kong d, Div Nephrol, Hong Kong, Hong Kong
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 7, volume: 92, anno: 1999,
pagine: 401 - 406
SICI:
1460-2725(199907)92:7<401:CFATOO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEPHROTIC SYNDROME; NATURAL-HISTORY; GLOMERULONEPHRITIS; TRIAL; ADULTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Tang, S Univ Hong Kong, Queen Mary Hosp, Dept Med, Div Nephrol, Pokfulam Rd, Hong Kong, Hong Kong Univ Hong Kong Pokfulam Rd Hong Kong Hong Kong g Kong, Hong Kong
Citazione:
S. Tang et al., "Clinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients", QJM-MON J A, 92(7), 1999, pp. 401-406

Abstract

We retrospectively studied the clinical course and treatment outcome of idiopathic membranous nephropathy (IMN) amongst 38 Chinese patients (25 male,13 female, age 51.6+/-14.6 years, follow-up duration 58.2+/-51.1 months) who presented over a 10-year review period. Eight never received any form ofspecific treatment (group I), seven received oral corticosteroid alone for6-9 months (group II), 17 were given corticosteroid plus cyclophosphamide for 6-12 months (group III), and six were treated with methylprednisolone alternating with chlorambucil every other month for 6 months (group IV). No untoward effect from drugs sufficient to alter the dosage used was recorded. After 6 months of treatment, over 50% of patients went into remission: a significant reduction in proteinuria (p=0.01, 0.01, 0.02) with a corresponding rise in serum albumin levels (p=0.01, 0.01, 0.04) was observed in groups II, III, and IV, respectively, but not in group I. During follow-up, one patient in each of groups I, III, IV, and two of group II developed renal function deterioration, which correlated with an abnormal presenting serum creatinine. In six group I and eight group III patients who have been followed for at least 5 years, there was progressive reduction in proteinuria in group III (p<0.05), but not in group I: serum creatinine has remained unchanged in both groups. IMN runs a benign course in Chinese patients in Hong Kong, with 2.6% of patients going into end-stage renal failure during the study period. Contrary to reports in Caucasians, there is similar treatment response to steroid alone or a combination of steroid and cytotoxic agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:59:37