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Titolo:
Biochemical markers of intelligence: a proton MR spectroscopy study of normal human brain
Autore:
Jung, RE; Brooks, WM; Yeo, RA; Chiulli, SJ; Weers, DC; Sibbitt, WL;
Indirizzi:
Univ New Mexico, Hlth Sci Ctr, Clin & Magnet Resonance Res Ctr, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 s Ctr, Albuquerque, NM 87131 USA Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ychol, Albuquerque, NM 87131 USA Univ New Mexico, Dept Rheumatol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 matol, Albuquerque, NM 87131 USA Univ New Mexico, Dept Neurosci, Albuquerque, NM 87131 USA Univ New MexicoAlbuquerque NM USA 87131 rosci, Albuquerque, NM 87131 USA St Josephs Rehabil Hosp, Albuquerque, NM 87131 USA St Josephs Rehabil Hosp Albuquerque NM USA 87131 lbuquerque, NM 87131 USA
Titolo Testata:
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1426, volume: 266, anno: 1999,
pagine: 1375 - 1379
SICI:
0962-8452(19990707)266:1426<1375:BMOIAP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; IN-VIVO; HEPATIC-ENCEPHALOPATHY; N-ACETYLASPARTATE; H-1 MRS; IQ; INDIVIDUALS; LOBE;
Keywords:
intelligence; proton magnetic resonance spectroscopy; choline; N-acetylaspartate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Brooks, WM Univ New Mexico, Hlth Sci Ctr, Clin & Magnet Resonance Res Ctr,1201 Yale Blvd NE, Albuquerque, NM 87131 USA Univ New Mexico 1201 Yale Blvd NE Albuquerque NM USA 87131 USA
Citazione:
R.E. Jung et al., "Biochemical markers of intelligence: a proton MR spectroscopy study of normal human brain", P ROY SOC B, 266(1426), 1999, pp. 1375-1379

Abstract

Proton magnetic resonance spectroscopy (H-1-MRS) offers a unique non-invasive approach to measurement of N-acetylaspartate (NAA) and choline (Cho), putative markers of neuronal and glial integrity. Previous studies revealed that these neurochemicals predict cognitive impairment in diseased subjects, although little is known about their relationship to cognitive functioning in healthy people. We measured the concentrations of NAA and Cho in the left occipitoparietal white matter of 26 healthy adults and compared them with intellectual performance assessed by the Wechsler Adult Intelligence Scale-3. We found that NAA (b = 0.6, p < 0.01) and Cho (b = -0.42, p < 0.01) were independently associated with the Full-Scale Intelligence Quotient. Together, these metabolites accounted for a large proportion of the variance in intelligence (r(2) = 0.45). Possible mechanisms underlying these correlations, such as mitochondrial function and myelin turnover, are discussed. H-1-MRS is a sensitive new tool to assess the neuronal underpinnings of cognitive function non-invasively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:49:15