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Titolo:
Measurement of specific IgEs in the diagnosis of drug allergy
Autore:
Anania, A;
Indirizzi:
Univ Turin, Dept Internal Med, Chair Internal Med 2, Allergol Out PatientsClin, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 ol Out PatientsClin, I-10126 Turin, Italy
Titolo Testata:
PANMINERVA MEDICA
fascicolo: 2, volume: 41, anno: 1999,
pagine: 115 - 117
SICI:
0031-0808(199906)41:2<115:MOSIIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANAPHYLACTOID REACTIONS; PREVIOUS ANESTHESIA; PENICILLIN ALLERGY; POPULATION; ATOPY;
Keywords:
drug hypersensitivity; aspirin adverse effects; antiinflammatory agents, non steroidal adverse effects; antibiotics, adverse effects; IgE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Anania, A Univ Turin, Dept Internal Med, Chair Internal Med 2, Allergol Out PatientsClin, Corso AM Dogliotti 14, I-10126 Turin, Italy Univ Turin Corso AM Dogliotti 14 Turin Italy I-10126 rin, Italy
Citazione:
A. Anania, "Measurement of specific IgEs in the diagnosis of drug allergy", PANMIN MED, 41(2), 1999, pp. 115-117

Abstract

Background. The anamnesis and, in certain cases, skin tests are indispensable methods for the correct diagnosis of allergy to drugs. However, in somecases, these two techniques alone, prove insufficient in achieving reliable predictive elements for drug allergies. Besides, the use of skin testing is often discouraged, due to the potential risks involved. Methods. In this study, the diagnostic efficiency of the measurement of specific IgE for a selected group of 13 drugs was evaluated. The test was carried out on 96 patients showing clinical signs directly attributable to theadministration of one particular drug (in 38 of the 96 cases) or more drugs (58/96 cases). The symptoms appeared after a week or more from the beginning of the drug treatment; this time interval is compatible with the development of an immune response. Results. The drugs most frequently causing adverse reactions were salicylic acid, noramidopyrin, propiphenazone, other non-steroidal anti-inflammatory drugs (NSAIDs), trimetoprim, antibiotics. RAST was applied to 13 drugs and was positive for at least one of the drugs tested in 31/96 patients. Conclusions. The results of the study confirm the validity of the RAST technique as a useful element in improving and making the overall diagnosis ofallergies to drugs more reliable.

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Documento generato il 26/01/21 alle ore 04:30:06