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Titolo:
On the role of gastrin-releasing peptide in meal-stimulated exocrine pancreatic secretion
Autore:
Horstmann, O; Nustede, R; Schmidt, W; Stockmann, F; Becker, H;
Indirizzi:
Univ Gottingen, Klin Allgemeinchirurg, Dept Surg, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 urg, D-37075 Gottingen, Germany Ruhr Univ Bochum, St Josef Hosp, Dept Med 1, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 ept Med 1, D-4630 Bochum, Germany Krankenhaus Friedrichshain, Dept Internal Med, Berlin, Germany KrankenhausFriedrichshain Berlin Germany Internal Med, Berlin, Germany
Titolo Testata:
PANCREAS
fascicolo: 2, volume: 19, anno: 1999,
pagine: 126 - 132
SICI:
0885-3177(199908)19:2<126:OTROGP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLASE RELEASE; ACINAR-CELLS; AMPHIBIAN SKIN; NEUROTENSIN; BOMBESIN; CHOLECYSTOKININ; DOGS; RAT; SECRETAGOGUES; L-364,718;
Keywords:
exocrine pancreas; GRP; CCK; neurotensin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Horstmann, O Univ Gottingen, Klin Allgemeinchirurg, Dept Surg, Robert KochStr, D-37075Gottingen, Germany Univ Gottingen Robert Koch Str Gottingen Germany D-37075 any
Citazione:
O. Horstmann et al., "On the role of gastrin-releasing peptide in meal-stimulated exocrine pancreatic secretion", PANCREAS, 19(2), 1999, pp. 126-132

Abstract

The contribution of gastrin-releasing peptide (GRP) in the physiologic pancreatic response to a meal is unknown. We therefore investigated whether immunoneutralization of GRP could influence the exocrine pancreatic response to a meal as well as plasma concentrations of the peptide hormones neurotensin (NT) and cholecystokinin (CCK). Modified Herrera fistulas were implanted in five mongrel dogs. After a standard meal, we analyzed plasma NT, CCK, and GRP, and protein and enzyme (amylase, lipase, trypsin) content of exocrine pancreatic juice. An unspecific rabbit immunoglobulin solution was administered intravenously as a control. This experiment was repeated with a specific anti-GRP-immunoglobulin. The i.v. administration of the anti-GRP-antibody significantly inhibited meal-stimulated pancreatic secretion. Integrated protein output decreased from 58.4 to 36.8 g/180 min (p < 0.05), as didamylase (2,102 to 1,145 KU/180 min; p < 0.05), lipase (2,258 to 1,172 KU/180 min; p < 0.05), and trypsin (5,321 to 4,990 U/180 min). Postprandially released NT decreased from 8,271 to 5,825 pmol/180 min (p < 0.05). In contrast, integrated amounts of CCK remained relatively stable with 473 to 611 pmol/180 min. The neuropeptide GRP is one of the biologically important regulatory factors influencing meal-stimulated pancreatic secretion, as well as the postprandial plasma level of the peptide hormone NT in the dog. These mentioned effects of postprandially released GRP seem not to be mediated by CCK in an endocrine manner.

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Documento generato il 05/12/20 alle ore 18:23:46