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Titolo:
The effects of single and multiple episodes of theta patterned or high frequency stimulation on synaptic transmission from hippocampal area CA1 to the subiculum in rats
Autore:
Commins, S; Anderson, M; Gigg, J; OMara, SM;
Indirizzi:
Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Psychol, Dublin 2, Ireland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 270, anno: 1999,
pagine: 99 - 102
SICI:
0304-3940(19990730)270:2<99:TEOSAM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SPATIAL MEMORY; IN-VIVO;
Keywords:
synaptic plasticity; subiculum; long-term potentiation; high-frequency stimulation; hippocampal formation; learning and memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: O'Mara, SM Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 , Dublin 2, Ireland
Citazione:
S. Commins et al., "The effects of single and multiple episodes of theta patterned or high frequency stimulation on synaptic transmission from hippocampal area CA1 to the subiculum in rats", NEUROSCI L, 270(2), 1999, pp. 99-102

Abstract

Long-term potentiation (LIP) is a popular model for the synaptic changes that may occur during learning and memory; it involves a strengthening of synaptic response and is readily induced in the hippocampus, an area of the brain implicated in learning and memory. Previous research on LTP has focused on 'early' components of the hippocampal circuitry, that is, the dentate gyrus and areas CA1 and CA3. This paper examines the plasticity of the CA1-subiculum pathway; we extend our previous work in this area demonstrating that the projection from area CA1 to subiculum sustains theta-patterned stimulus-induced LTP in vivo. We show that this pathway remains potentiated over a long period (3 h). Furthermore, once this projection is potentiated, itseems resistant to further episodes of high-frequency stimulation. We discuss the implications of these findings for theories of hippocampal-corticalinteraction during the biological consolidation of memory. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:31:55