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Titolo:
Adenovirus-mediated gene transfer of Bcl-xL prevents cell death in primaryneuronal culture of the rat
Autore:
Matsuoka, N; Yukawa, H; Ishii, K; Hamada, H; Akimoto, M; Hashimoto, N; Miyatake, S;
Indirizzi:
Kyoto Univ, Fac Med, Dept Neurosurg & Clin Neurosci, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Neurosci, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Virus Res, Sakyo Ku, Kyoto 6068507, Japan Japanese Fdn Canc Res, Inst Canc, Ctr Canc Chemotherapy, Dept Mol Biotherapy Res,Toshima Ku, Tokyo 170, Japan Japanese Fdn Canc Res Tokyo Japan 170y Res,Toshima Ku, Tokyo 170, Japan Shinshu Univ, Dept Ophthalmol, Nagano 3900802, Japan Shinshu Univ NaganoJapan 3900802 Dept Ophthalmol, Nagano 3900802, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 270, anno: 1999,
pagine: 177 - 180
SICI:
0304-3940(19990806)270:3<177:AGTOBP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURVIVAL; APOPTOSIS; HOMOLOG; SYSTEM;
Keywords:
adenovirus; apoptosis; Bcl-xL; gene transfer; neuronal cell death; primary neuronal culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Miyatake, S Kyoto Univ, Fac Med, Dept Neurosurg & Clin Neurosci, Sakyo Ku,54 KawaharaCho, Kyoto 6068507, Japan Kyoto Univ 54 Kawahara Cho Kyoto Japan 6068507 6068507, Japan
Citazione:
N. Matsuoka et al., "Adenovirus-mediated gene transfer of Bcl-xL prevents cell death in primaryneuronal culture of the rat", NEUROSCI L, 270(3), 1999, pp. 177-180

Abstract

Bcl-xL is a Bcl-2-related gene that regulates programmed cell death in a bcl-2-independent fashion. It is expressed in tissues containing long-surviving postmitotic cells, such as neurons in adult brains. To investigate the possibility of gene therapy for transferring this anti-apoptotic gene into the neuron for the treatment of vascular occlusive or neurodegenerative diseases, we examined the effect of a replication-deficient recombinant adenovirus vector coding human Bcl-xL gene on the augmentation of the survival ofprimarily-cultured rat neuronal cells in vitro. Immunoblot analysis revealed that primarily-cultured neuronal cells were successfully infected and transferred with this gene by recombinant adenovirus vector with high transduction efficiency. Bcl-xL gene transfer to the primarily-cultured neurons could prevent these cells from cell death. (C) 1999 Elsevier Science Ireland ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:50:44