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Titolo:
Tenascin-R and C in multiple sclerosis lesions: relevance to extracellularmatrix remodelling
Autore:
Gutowski, NJ; Newcombe, J; Cuzner, ML;
Indirizzi:
Inst Neurol, Multiple Sclerosis Lab, London WC1N 3BG, England Inst NeurolLondon England WC1N 3BG erosis Lab, London WC1N 3BG, England
Titolo Testata:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
fascicolo: 3, volume: 25, anno: 1999,
pagine: 207 - 214
SICI:
0305-1846(199906)25:3<207:TACIMS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA; CELL-ADHESION; GROWTH-FACTOR; BRAIN INJURY; EXPRESSION; ADULT; LOCALIZATION; PROTEIN; RAT;
Keywords:
extracellular matrix; glial scar; macrophages; multiple sclerosis; tenascin-C; tenascin-R;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Gutowski, NJ Royal Devon & Exeter Hosp, Dept Neurol, Barrack Rd, Exeter EX2 5DW, Devon,England Royal Devon & Exeter Hosp Barrack Rd Exeter Devon England EX2 5DW
Citazione:
N.J. Gutowski et al., "Tenascin-R and C in multiple sclerosis lesions: relevance to extracellularmatrix remodelling", NEUROP AP N, 25(3), 1999, pp. 207-214

Abstract

In the present study the distribution of the inhibitory extracellular molecules tenascin-R (TN-R) and tenascin-C (TN-C) was examined by immunocytochemistry during evolution of the multiple sclerosis (MS) lesion, in which astrogliosis is a prominent feature. Sections were cut from five control casesand from 22 blocks containing lesions representing different pathological stages in 18 cases of secondary progressive MS. Widespread expression of TN-R was found in the normal human central nervous system (CNS), while that of TN-C was in general restricted to white matter. In acute MS plaques however, there was a similar striking loss of both TN-R and TN-C up to the edge of the lesion, where the macrophage density is greatest, extending into theapparently normal white matter. In subacute lesions a TN-C and/or TN-R-immunopositive reactive astrocyte subpopulation was prominent, reflecting synthesis of extracellular matrix molecules. Both tenascins were expressed throughout chronic MS plaques at levels similar to those seen in adjacent whitematter. The loss of TN-R and TN-C in acute plaques is indicative of enzyme-mediated breakdown of the matrix which may be a marl;er of blood-brain barrier breakdown and leucocyte extravasation. Subsequent production of tenascins by reactive astrocytes may result in glial scar formation impeding remyelination and axonal repair in MS lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 12:59:59