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Titolo:
A new animal model to study intimal hyperplasia in arteriovenous fistulas
Autore:
Lemson, MS; Daemen, MJAP; Kitslaar, PJEHM; Tordoir, JHM;
Indirizzi:
Univ Hosp Maastricht, Dept Surg, Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands rg, Maastricht, Netherlands Univ Hosp Maastricht, Dept Pathol, Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands ol, Maastricht, Netherlands Maastricht Univ, CARIM, Maastricht, Netherlands Maastricht Univ Maastricht Netherlands , CARIM, Maastricht, Netherlands
Titolo Testata:
JOURNAL OF SURGICAL RESEARCH
fascicolo: 1, volume: 85, anno: 1999,
pagine: 51 - 58
SICI:
0022-4804(199907)85:1<51:ANAMTS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOGENOUS VEIN GRAFTS; VASCULAR GRAFTS; CELLULAR PROLIFERATION; MEDIAL HYPERPLASIA; LOOP GRAFTS; ARTERIES; INJURY; PROSTHESES; INHIBITION; BABOON;
Keywords:
intimal hyperplasia; vascular access; arteriovenous fistula; polytetrafluoroethylene; animal model; goat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lemson, MS Univ Hosp Maastricht, Dept Surg, Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands cht, Netherlands
Citazione:
M.S. Lemson et al., "A new animal model to study intimal hyperplasia in arteriovenous fistulas", J SURG RES, 85(1), 1999, pp. 51-58

Abstract

Background. Intimal hyperplasia (IH) plays a key role in the failure of arteriovenous (AV) fistulas. The animal models available to study IH in AV fistulas are expensive and do not mimic the development of truly stenotic IH. In this study we examined whether goats are a more suitable model to studyIH in AV fistulas. Materials and Methods. Thirteen direct and four bridge graft AV fistulas between the carotid artery and the jugular vein of goats were explanted 10 to 195 days after creation. Immunohistochemical staining and morphometric measurements of intima and media were performed in the artery, the vein, the toe, and the heel of the venous anastomosis. Ratios of intimal to medial thickness (I-th/M-th) and area (I-a/M-a) were calculated. Results. IH developed in all goats, mainly at the anastomosis (I-a/M-a = 0.17) and the efferent vein (I-a/M-a = 0.31). The artery was almost free of lesions (I-a/M-a = 0.03). In the efferent vein, I-th/M-th varied between 0.59 and 0.68. In the anastomosis the largest value of I-th/M-th, was measured at the suture lines (0.88 and 0.91). Absolute intimal area increased withtime. IH contained many vascular smooth muscle cells with a patchy displayof desmin positivity, an abundance of smooth muscle cell alpha-actin positivity, and almost complete endothelial cell coverage. Occlusion was due to thrombus formation on the IH. Conclusion. A clear intimal hyperplasia developed in AV fistulas in goats at locations comparable to those in humans. Therefore, the AV fistula modelin the goat may be seen as an effective model to study IH in hemodialysis AV fistulas. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:51:21