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Titolo:
Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat
Autore:
Dragoi, G; Carpi, D; Recce, M; Csicsvari, J; Buzsaki, G;
Indirizzi:
Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA RutgersState Univ Newark NJ USA 07102 hav Neurosci, Newark, NJ 07102 USA New Jersey Inst Technol, Dept Comp Sci, Newark, NJ 07102 USA New Jersey Inst Technol Newark NJ USA 07102 omp Sci, Newark, NJ 07102 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 14, volume: 19, anno: 1999,
pagine: 6191 - 6199
SICI:
0270-6474(19990715)19:14<6191:IBHAMS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
URETHANE ANESTHETIZED RATS; DIAGONAL BAND; INTRACELLULAR-RECORDINGS; CHOLINE-ACETYLTRANSFERASE; INHIBITORY INTERNEURONS; PYRAMIDAL NEURONS; GABAERGIC NEURONS; CROSS-CORRELATION; LATERAL SEPTUM; GUINEA-PIG;
Keywords:
EEG; GABAergic neurons; interneurons; ripples; cholinergic system; lateral septum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Buzsaki, G Rutgers State Univ, Ctr Mol & Behav Neurosci, 197 Univ Ave, Newark, NJ 07102 USA Rutgers State Univ 197 Univ Ave Newark NJ USA 07102 J 07102 USA
Citazione:
G. Dragoi et al., "Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat", J NEUROSC, 19(14), 1999, pp. 6191-6199

Abstract

The medial septal region and the hippocampus are connected reciprocally via GABAergic neurons, but the physiological role of this loop is still not well understood. In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta activity and extracellular units recorded in the medial septum and diagonal band of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%) were significantly suppressed during SPWs. Most cells inhibited during SPW (80%) fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal layer theta waves. Because both SPW and the negative peak of local theta waves correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron classes, thefindings indicate that the activity of medial septal neurons can be negatively (during SPW) or positively (during theta waves) correlated with the activity of hippocampal interneurons. We hypothesize that the functional coupling between medial septal neurons and hippocampal interneurons varies in astate-dependent manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:54:33