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Titolo:
Cytokines in the induction and circumvention of peripheral tolerance
Autore:
Romball, CG; Weigle, WO;
Indirizzi:
Scripps Clin & Res Inst, Dept Immunol, La Jolla, CA 92037 USA Scripps Clin& Res Inst La Jolla CA USA 92037 nol, La Jolla, CA 92037 USA
Titolo Testata:
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
fascicolo: 6, volume: 19, anno: 1999,
pagine: 671 - 678
SICI:
1079-9907(199906)19:6<671:CITIAC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; IN-VIVO; IMMUNOLOGICAL-TOLERANCE; LYMPHOKINE SECRETION; CLONAL EXPANSION; IFN-GAMMA; SUBSETS; MICE; HELPER; IL-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Weigle, WO Scripps Clin & Res Inst, Dept Immunol, IMM-9,10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst IMM-9,10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
C.G. Romball e W.O. Weigle, "Cytokines in the induction and circumvention of peripheral tolerance", J INTERF CY, 19(6), 1999, pp. 671-678

Abstract

Injection of deaggregated (monomeric) human gamma globulin (DHGG) into mice induces a state of immunological tolerance to subsequent challenge with immunogenic forms of HGG. Tolerance was shown to be induced in both the Th1 and Th2 CD4(+) subsets. These mice fail to demonstrate antibody production,T cell proliferation, cytokine release, or T cell helper function. On the other hand, simultaneous injection of lipopolysaccharide (LPS) as well as interleukin-1 (IL-1) was capable of interfering with the induction of tolerance to DHGG. The purpose of the present study is to extend these investigations to determination of the cellular mechanisms responsible for the interference of tolerance induction in both CD4+ T cell subsets. It was demonstrated that LPS and IL-1 have differential effects on the induction of tolerance in the CD4(+) subsets. As evidenced by immunoglobulin G (IgG) subclass, T helper cell function, and lymphokine secretion, coinjection of LPS with tolerogen interfered with the induction of tolerance in both subsets, whereas IL-1 interfered with the induction of tolerance exclusively in the Th1 subset. LPS and IL-1 had differential effects on the interference of the induction of tolerance in LPS-resistant mice where IL-1, but not LPS, was effective. In contrast to IL-1, IL-12 injected along with DHGG failed to interfere with the induction of tolerance in either Th1 or Th2 cells. Previous studies that demonstrated tolerance in the DHGG models induced in both the Th1and Th2 subsets was further suggested by the demonstrations in the presentstudy that dose-response curves for the induction of tolerance are identical in both subsets. The above findings taken together are compatible with the suggestion that tolerance induction results from the lack of cytokine production, which then prevents the expansion of Th1 and Th2 subsets following activation of the CD4(+) precursor T cell. Furthermore, they support the general opinion that the expansion of these two subsets involve different cytokine pathways and that LPS and IL-1 most likely act through different cell receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:25:41