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Titolo:
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
Autore:
Rufer, N; Brummendorf, TH; Kolvraa, S; Bischoff, C; Christensen, K; Wadsworth, L; Schulzer, M; Lansdorp, PM;
Indirizzi:
British Columbia Canc Res Ctr, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada British Columbia Canc Res Ctr Vancouver BC Canada V5Z 1L3 V5Z 1L3, Canada Aarhus Univ, Inst Human Genet, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus Denmark DK-8000 Human Genet, DK-8000 Aarhus, Denmark Odense Univ, Sch Med, Inst Publ Hlth, DK-5000 Odense, Denmark Odense UnivOdense Denmark DK-5000 st Publ Hlth, DK-5000 Odense, Denmark British Columbia Childrens Hosp, Dept Pathol, Vancouver, BC V6H 3V4, Canada British Columbia Childrens Hosp Vancouver BC Canada V6H 3V4 H 3V4, Canada Univ British Columbia, Dept Med, Vancouver, BC V6T 2B5, Canada Univ British Columbia Vancouver BC Canada V6T 2B5 ver, BC V6T 2B5, Canada Univ British Columbia, Dept Stat, Vancouver, BC V6T 2B5, Canada Univ British Columbia Vancouver BC Canada V6T 2B5 ver, BC V6T 2B5, Canada
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 2, volume: 190, anno: 1999,
pagine: 157 - 167
SICI:
0022-1007(19990719)190:2<157:TFMIGA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT BONE-MARROW; REPLICATIVE SENESCENCE; FETAL LIVER; HUMAN FIBROBLASTS; BLOOD-CELLS; B-CELL; LENGTH; AGE; ACTIVATION; EXPRESSION;
Keywords:
telomere length dynamics; telomere length inheritance; cellular turnover; immune senescence; stem cell self-renewal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Lansdorp, PM British Columbia Canc Res Ctr, Terry Fox Lab, 601 W 10th Ave,Vancouver, BC V5Z 1L3, Canada British Columbia Canc Res Ctr 601 W 10th AveVancouver BC Canada V5Z 1L3
Citazione:
N. Rufer et al., "Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood", J EXP MED, 190(2), 1999, pp. 157-167

Abstract

To study telomere length dynamics in hematopoietic cells with age, we analyzed the average length of telomere repeat sequences in diverse populationsof nucleated blood cells. More than 500 individuals ranging in age from 0 to 90 yr, including 36 pairs of monozygous and dizygotic twins, were analyzed using quantitative fluorescence in situ hybridization and now cytometry. Granulocytes and naive T cells showed a parallel biphasic decline in telomere length with age that most likely reflected accumulated cell divisions in the common precursors of both cell types: hematopoietic stem cells. Telomere loss was very rapid in the first year, and continued for more than eight decades at a 30-fold lower rate. Memory T cells also showed an initial rapid decline in telomere length with age. However, in contrast to naive T cells, this decline continued for several years, and in older individuals lymphocytes typically had shorter telomeres than did granulocytes. Our findings point to a dramatic decline in stem cell turnover in early childhood and support the notion that cell divisions in hematopoietic stem cells and T cells result in loss of telomeric DNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:11:31