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Titolo:
Field evaluation of the ICT malaria P.f/P.v immunochromatographic test fordetection of Plasmodium falciparum and Plasmodium vivax in patients with apresumptive clinical diagnosis of malaria in eastern Indonesia
Autore:
Tjitra, E; Suprianto, S; Dyer, M; Currie, BJ; Anstey, NM;
Indirizzi:
Menzies Sch Hlth Res, Trop Med & Int Hlth Unit, Darwin, NT 0811, AustraliaMenzies Sch Hlth Res Darwin NT Australia 0811 Darwin, NT 0811, Australia Natl Inst Hlth Res & Dev, Communicable Dis Res Ctr, Jakarta, Indonesia Natl Inst Hlth Res & Dev Jakarta Indonesia Res Ctr, Jakarta, Indonesia Directorate Gen Communicable Dis Control & Enviro, Jakarta, Indonesia Directorate Gen Communicable Dis Control & Enviro Jakarta Indonesia sia
Titolo Testata:
JOURNAL OF CLINICAL MICROBIOLOGY
fascicolo: 8, volume: 37, anno: 1999,
pagine: 2412 - 2417
SICI:
0095-1137(199908)37:8<2412:FEOTIM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-CAPTURE ASSAY; PARASIGHT-F TEST; DIPSTICK TEST; INFECTION; PERFORMANCE; SYSTEM; GUIDES; TOOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Anstey, NM Menzies Sch Hlth Res, Trop Med & Int Hlth Unit, POB 41096, Darwin, NT 0811, Australia Menzies Sch Hlth Res POB 41096 Darwin NT Australia 0811 stralia
Citazione:
E. Tjitra et al., "Field evaluation of the ICT malaria P.f/P.v immunochromatographic test fordetection of Plasmodium falciparum and Plasmodium vivax in patients with apresumptive clinical diagnosis of malaria in eastern Indonesia", J CLIN MICR, 37(8), 1999, pp. 2412-2417

Abstract

In areas such as eastern Indonesia where both Plasmodium falciparum and Plasmodium vivax occur, rapid antigen detection tests for malaria need to be able to detect both species. We evaluated the new combined P. falciparum-P.vivax immunochromatographic test (ICT Malaria P,f/P.v.) in Radamata Primary Health Centre, Sumba, Indonesia, from February to May 1998 with 560 symptomatic adults and children with a presumptive clinical diagnosis of malaria, Blinded microscopy was used as the "gold standard," with all discordant and 20% of concordant results cross-checked blindly. Only 50% of those with a presumptive clinical diagnosis of malaria were parasitemic. The ICT Malaria P,f/P,v immunochromatographic test was sensitive (95.5%) and specific (89.8%) for the diagnosis of falciparum malaria, with a positive predictive value (PPV) and a negative predictive value (NPV) of 88.1 and 96.2%, respectively. HRP2. and panmalarial antigen line intensities were associated with parasitemia density for both species, Although the specificity and NPV for the diagnosis of vivax malaria were 94.8 and 98.2%, respectively, the overall sensitivity (75%) and PPV (50%) for the diagnosis of vivax malaria were less than the desirable levels. The sensitivity for the diagnosis of P. vivax malaria,vas 96% with parasitemias of > 500/mu l but only 29% with parasitemias of < 500/mu l. Nevertheless, compared with the test with HRP2 alone,use of the combined antigen detection test would reduce the rate of undertreatment from 14.7 to 3.6% for microscopy-positive patients, and this wouldbe at the expense of only a modest increase in the rate of overtreatment of microscopy-negative patients from 7.1 to 15.4%. Cost remains a major obstacle to widespread use in areas of endemicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:01:13