Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
O-6-methylguanine-DNA methyltransferase gene (MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation
Autore:
Rolhion, C; Penault-Llorca, F; Kemeny, JL; Kwiatkowski, F; Lemaire, JJ; Chollet, P; Finat-Duclos, F; Verrelle, P;
Indirizzi:
Ctr Jean Perrin, Lab Transfert Oncol Predict, F-63011 Clermont Ferrand 1, France Ctr Jean Perrin Clermont Ferrand France 1 011 Clermont Ferrand 1, France INSERM, U484, Clermont Ferrand, France INSERM Clermont Ferrand FranceINSERM, U484, Clermont Ferrand, France Hop Gabriel Montpied, Anat Pathol Lab, Clermont Ferrand, France Hop Gabriel Montpied Clermont Ferrand France , Clermont Ferrand, France Ctr Jean Perrin, Serv Biostat, Clermont Ferrand, France Ctr Jean Perrin Clermont Ferrand France ostat, Clermont Ferrand, France Hop Fontmaure, Serv Neurochirurg, Chamalieres, France Hop Fontmaure Chamalieres France Serv Neurochirurg, Chamalieres, France Ctr Jean Perrin, Dept Med Oncol, Clermont Ferrand, France Ctr Jean PerrinClermont Ferrand France Oncol, Clermont Ferrand, France Ctr Jean Perrin, Dept Radiotherapie, Clermont Ferrand, France Ctr Jean Perrin Clermont Ferrand France rapie, Clermont Ferrand, France
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 4, volume: 84, anno: 1999,
pagine: 416 - 420
SICI:
0020-7136(19990820)84:4<416:OMG(EI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-TUMORS; DNA-REPAIR; SURVIVAL; GLIOMAS; CHEMOTHERAPY; RADIATION; CHLOROETHYLNITROSOUREA; MUTATIONS; THERAPY; MDM2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Rolhion, C Ctr Jean Perrin, Lab Transfert Oncol Predict, BP 392, F-63011 Clermont Ferrand 1, France Ctr Jean Perrin BP 392 Clermont Ferrand France 1and 1, France
Citazione:
C. Rolhion et al., "O-6-methylguanine-DNA methyltransferase gene (MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation", INT J CANC, 84(4), 1999, pp. 416-420

Abstract

Repair of cytotoxic DNA damage by O-6-methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CE-NUs), commonly used in the treatment of glioblastoma multiforme (GBM). The value of p53 as a prognostic factor in GBMs remains unclear, but a possible relationship between MGMT gene expression and p53 has beensuggested. To further examine these GEM characteristics in vivo, we assessed MGMT gene expression using semi-quantitative RT-PCR and p53 alteration by immuno-histochemistry on a series of 39 GBMs. MGMT gene expression was inversely correlated with age (p < 0.03), consistent with the results of others. Interestingly, tumors from male patients had higher MGMT mRNA amounts than tumors from female patients (p < 0.03). No prognostic implication was observed either for MGMT gene expression or for p53 accumulation. However, MGMT gene expression was significantly lower in p53-altered GEM, regardless of the percentage of positive cells (p < 0.01). Our observation suggests that in human glial tumors, a low level of MGMT gene expression might promotep53 alteration, probably via mutation of its gene. Int. J. Cancer (Pred. Oncol.) 84:416-420, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:07:52