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Titolo:
Effects of tiapride on electroencephalograms and cognitive functions in the elderly
Autore:
Patat, A; Alberini, H; Bonhomme, D; Soubrane, C; Allain, H; Gandon, JM;
Indirizzi:
Biotrial SA, Drug Evaluat & Pharmacol Res, Technopole Atalante Villejean, Rennes, France Biotrial SA Rennes France Technopole Atalante Villejean, Rennes, France Labs Synthelabo, Meudon La Foret, France Labs Synthelabo Meudon La ForetFrance thelabo, Meudon La Foret, France Synthelabo Rech, Bagneux, France Synthelabo Rech Bagneux FranceSynthelabo Rech, Bagneux, France CHRU Pontchaillou, Serv Pharmacol, Rennes, France CHRU Pontchaillou Rennes France haillou, Serv Pharmacol, Rennes, France
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 14, anno: 1999,
pagine: 199 - 208
SICI:
0268-1315(199907)14:4<199:EOTOEA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOMOTOR PERFORMANCE; HEALTHY-VOLUNTEERS; LORAZEPAM; DIAZEPAM; MEMORY; SEDATION; SINGLE; ALPRAZOLAM; RECEPTORS; CLOBAZAM;
Keywords:
elderly; psychomotor performance; cognitive functions; EEG; tiapride; lorazepam; behavioural disturbance in dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Patat, A Wyeth Ayerst Res, Clin Pharmacol, 80 Ave Charles de Gaulle, F-92031 Paris La Def, France Wyeth Ayerst Res 80 Ave Charles de Gaulle Paris La Def France F-92031
Citazione:
A. Patat et al., "Effects of tiapride on electroencephalograms and cognitive functions in the elderly", INT CLIN PS, 14(4), 1999, pp. 199-208

Abstract

Tiapride is a substituted benzamide with selective dopamine D-2 and D-3-antagonist properties which appears to have preferential affinity for extra-striatal dopamine receptors. Tiapride is used in the treatment of agitation,aggressiveness and anxiety in the elderly. To define the effects of a single dose of tiapride 100 mg on psychomotor peformance and cognitive functions and electroencephalogram (EEG), a randomized, double-blind, three-way crossover, placebo-controlled study using lorazepam 1 mg as a positive controlwas carried out in 12 elderly individuals (six women and six men, mean age+/- SD: 69 +/- 3 years). A 1-week wash-out interval was allowed between each administration. Psychomotor and cognitive functions were assessed using both objective [EEG, critical flicker fusion, simple reaction time, tapping, body sway, continuous performance task (CPT), digit symbol substitution test, Sternberg memory scanning and a learning memory test using word lists]and subjective (visual analogue scales) measures before and up to 6 h after dosing. Tiapride was devoid of any detrimental or sedative effects on EEGand all of the performance tasks used and did not impair memory compared with placebo. In contrast, a single dose of lorazepam produced significant deleterious effects on psychomotor performance (decrease in tapping and in sustained attention (CPT) and an increase in reaction time and body sway), and sedative effects on EEG (significant increase in delta and decrease in alpha waves) as well as significant impairment in working memory (Sternberg)and anterograde amnesia (decrease in immediate and delayed free recall) upto 6 h after dosing compared with placebo and tiapride. In conclusion, thepresent study showed that in contrast to lorazepam 1 mg there is no evidence to suggest that a single dose of tiapride 100 mg has any sedative and amnestic effects in the elderly which may interfere with everyday life activities. Int Clin Psychopharmacol 14:199-208 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:29:47