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Titolo:
Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice
Autore:
Montine, TJ; Montine, KS; Olson, SJ; Graham, DG; Roberts, LJ; Morrow, JD; Linton, MF; Fazio, S; Swift, LL;
Indirizzi:
Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Dept Med, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 pt Pathol, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Ctr Mol Neurosci, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Neurosci, Nashville, TN 37232 USA
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 158, anno: 1999,
pagine: 234 - 241
SICI:
0014-4886(199907)158:1<234:ICCLPA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; CENTRAL-NERVOUS-SYSTEM; E KNOCKOUT MICE; APOLIPOPROTEIN-E; ALZHEIMERS-DISEASE; NEURITE OUTGROWTH; PLASMA-LIPOPROTEINS; IN-VIVO; BRAIN; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Montine, TJ Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 ashville, TN 37232 USA
Citazione:
T.J. Montine et al., "Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice", EXP NEUROL, 158(1), 1999, pp. 234-241

Abstract

Aged homozygous apolipoprotein E gene-deficient (apoE -/-) mice have been proposed as an experimental model for the role of human apoE isoforms in Alzheimer's disease (AD). However, results from different laboratories have been in conflict regarding the presence or absence of neurodegeneration in these mice. Moreover, despite apoE being the major lipid trafficking molecule in the central nervous system, there has been no investigation of brain Lipid levels in apoE -/- mice. Here we have examined male and female apoE -/- and control mice aged 10 to 12 months, testing the hypothesis that lack, of apoE leads to some of the neuropathological changes seen in AD. Our results failed to demonstrate significant neurodegeneration, histopathological changes, or reduction in cerebral cortical synaptophysin in apoE -/- mice. However, we did observe a significant reduction in cerebral cortical phospholipids and their constituent fatty acids, as well as elevated Lipid peroxidation products, in apoE -/- mice compared to apoE +/+ mice with the same genetic background. Our results suggest that the brains of aged apoE -/- mice display some of the lipid abnormalities associated with AD; however, these changes alone, at the magnitudes achieved in the apoE -/- mice, do not directly lead to the major neurodegenerative changes of AD. (C) 1999 AcademicPress.

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Documento generato il 04/12/20 alle ore 06:34:53