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Titolo:
Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles
Autore:
Cryderman, DE; Morris, EJ; Biessmann, H; Elgin, SCR; Wallrath, LL;
Indirizzi:
Univ Iowa, Dept Biochem, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 a, Dept Biochem, Iowa City, IA 52242 USA Univ Calif Irvine, Ctr Dev Biol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 Ctr Dev Biol, Irvine, CA 92697 USA Washington Univ, Dept Biol, St Louis, MO 63130 USA Washington Univ St Louis MO USA 63130 , Dept Biol, St Louis, MO 63130 USA
Titolo Testata:
EMBO JOURNAL
fascicolo: 13, volume: 18, anno: 1999,
pagine: 3724 - 3735
SICI:
0261-4189(19990701)18:13<3724:SADTNO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITION-EFFECT VARIEGATION; HETEROCHROMATIN-ASSOCIATED PROTEIN; SALIVARY-GLAND NUCLEI; GENE-EXPRESSION; TRANSPOSABLE ELEMENTS; CHROMOSOME REARRANGEMENTS; SACCHAROMYCES-CEREVISIAE; TRYPANOSOMA-BRUCEI; HSP26 PROMOTER; HET-A;
Keywords:
chromatin structure; Drosophila; nuclear organization; PEV; telomeres;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Wallrath, LL Univ Iowa, Dept Biochem, 4-772 Bowen Sci Bldg, Iowa City, IA 52242 USA Univ Iowa 4-772 Bowen Sci Bldg Iowa City IA USA 52242 242 USA
Citazione:
D.E. Cryderman et al., "Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles", EMBO J, 18(13), 1999, pp. 3724-3735

Abstract

Transgenes inserted into the telomeric regions of Drosophila melanogaster chromosomes exhibit position effect variegation (PEV), a mosaic silencing characteristic of euchromatic genes brought into juxtaposition with heterochromatin, Telomeric transgenes on the second and third chromosomes are flanked by telomeric associated sequences (TAS), while fourth chromosome telomeric transgenes are most often associated with repetitious transposable elements. Telomeric PEV on the second and third chromosomes is suppressed by mutations in Su(z)2, but not by mutations in Su(var)2-5 (encoding HP1), while the converse is true for telomeric PEV on the fourth chromosome. This genetic distinction allowed for a spatial and molecular analysis of telomeric PEV. Reciprocal translocations between the fourth chromosome telomeric regioncontaining a transgene and a second chromosome telomeric region result in a change in nuclear location of the transgene. While the variegating phenotype of the white transgene is suppressed, sensitivity to a mutation in HP1 is retained. Corresponding changes in the chromatin structure and inducibleactivity of an associated hsp26 transgene are observed. The data indicate that both nuclear organization and local chromatin structure play a role inthis telomeric PEV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 12:29:34