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Titolo:
Intrinsic electrophysiology of neurons in thalamorecipient layers of developing rat auditory cortex
Autore:
Metherate, R; Aramakis, VB;
Indirizzi:
Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ CalifIrvine Irvine CA USA 92697 obiol & Behav, Irvine, CA 92697 USA Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ning & Memory, Irvine, CA 92697 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 115, anno: 1999,
pagine: 131 - 144
SICI:
0165-3806(19990602)115:2<131:IEONIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL FOREBRAIN PROJECTIONS; VISUAL CORTICAL-NEURONS; PYRAMIDAL NEURONS; NEOCORTICAL NEURONS; FRONTAL-CORTEX; GABAERGIC INHIBITION; SYNAPTIC RESPONSES; FIRING PATTERNS; CONNECTIONS; CELLS;
Keywords:
sensory cortex; onset cell; intrinsic property; postnatal development; thalamocortical; outward rectification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Metherate, R Univ Calif Irvine, Dept Neurobiol & Behav, 2205 Biol Sci 2, Irvine, CA 92697 USA Univ Calif Irvine 2205 Biol Sci 2 Irvine CA USA 92697 697 USA
Citazione:
R. Metherate e V.B. Aramakis, "Intrinsic electrophysiology of neurons in thalamorecipient layers of developing rat auditory cortex", DEV BRAIN R, 115(2), 1999, pp. 131-144

Abstract

During early postnatal life, several critical events contribute to the functional development of rat sensory neocortex. Thalamocortical innervation of sensory cortex is completed during the first postnatal week and extrathalamic innervation develops over the first several weeks. In auditory cortex,acoustic-evoked potentials first occur in week 2 and develop most rapidly over weeks 2-3. Thus, rapid functional maturation of cortical circuits in sensory cortex occurs during the second and third postnatal weeks. The electrophysiological properties of cortical neurons that receive afferent inputsduring this time may play an important role in development and function. In this study we examined the intrinsic electrophysiology, including spikingpatterns, of neurons in layers II/III and IV of auditory cortex during postnatal weeks 2 and 3. Many neurons displayed characteristics consistent with previous descriptions of response classes (regular spiking, fast spiking,intrinsic bursting). In addition, we identified two groups, Rectifying andOn-spiking neurons, that were characterized by (i) brief spike trains in response to maintained intracellular depolarizations, and (ii) striking outward rectification upon depolarization. Unusually brief spike trains (1-2 spikes) and short spike latencies (<10 ms) further distinguished On-spiking from Rectifying cells. Biocytin labeling demonstrated that On-spiking and Rectifying cells could be either pyramidal or nonpyramidal neurons. The intrinsic physiology of these cell groups may play an important role in auditorycortex function. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:51:40