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Titolo:
Genes and hypertension: Where we are and where we should go
Autore:
Hamet, P;
Indirizzi:
CHU Montpellier, Montreal, PQ H2W 1T8, Canada CHU Montpellier Montreal PQCanada H2W 1T8 , Montreal, PQ H2W 1T8, Canada Mol Pathophysiol Lab, Montreal, PQ H2W 1T8, Canada Mol Pathophysiol Lab Montreal PQ Canada H2W 1T8 treal, PQ H2W 1T8, Canada
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 5-6, volume: 21, anno: 1999,
pagine: 947 - 960
SICI:
1064-1963(199907/08)21:5-6<947:GAHWWA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL SODIUM-CHANNEL; RECOMBINANT INBRED STRAINS; QUANTITATIVE TRAIT LOCI; BLOOD-PRESSURE; BETA-SUBUNIT; ALDOSTERONE SYNTHASE; CONGENIC STRAINS; RAT CHROMOSOME-2; LIDDLES-SYNDROME; POLYMORPHISMS;
Keywords:
genetics; hypertension; environment; candidate genes; hypertension loci;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Hamet, P CHU Montpellier, 3850 St Urbain St, Montreal, PQ H2W 1T8, Canada CHU Montpellier 3850 St Urbain St Montreal PQ Canada H2W 1T8 nada
Citazione:
P. Hamet, "Genes and hypertension: Where we are and where we should go", CLIN EXP HY, 21(5-6), 1999, pp. 947-960

Abstract

Our understanding of the genetics of hypertension is incomplete. A great deal has, however, been learned about the role of several "candidate" genes by altering their expression in transgenic and knockout models; Crosses of inbred strains, analyzed in F-2 generations, have demonstrated consistent quantitative trait loci, particularly on chromosomes 1, 2 and 10, suggestingsignificant contributions of some genes in distinct models of rodent hypertension. The effect of these loci has been tested in congenic strains and their interaction underlined in double congenics. The weakness of testing individual animals from F-2 crosses is overcome in recombinant inbred strains. In humans, Mendelian models of hypertension have contributed to progress in our understanding of this disease, but have not yet revealed any major gene of essential hypertension. Many association as well as linkage studies of humans have provided useful though somewhat contradictory data. Our renewed effort is oriented towards the discovery of genetic determinants of environmental interaction in hypertension as well as towards the future of pharmacogenomics. This progress will be the basis of future individualized treatment and prevention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:27:19