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Titolo:
Expression of the alpha 7 beta 1 laminin receptor suppresses melanoma growth and metastatic potential
Autore:
Ziober, BL; Chen, YQ; Ramos, DM; Waleh, N; Kramer, RH;
Indirizzi:
Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA SRI Int, Menlo Park, CA 94025 USA SRI Int Menlo Park CA USA 94025SRI Int, Menlo Park, CA 94025 USA
Titolo Testata:
CELL GROWTH & DIFFERENTIATION
fascicolo: 7, volume: 10, anno: 1999,
pagine: 479 - 490
SICI:
1044-9523(199907)10:7<479:EOTA7B>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; MURINE MELANOMA; INTEGRIN RECEPTOR; MALIGNANT-MELANOMA; SKELETAL MYOBLASTS; BINDING INTEGRINS; A CHAIN; ADHESION; MIGRATION; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Kramer, RH Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 94143 USA
Citazione:
B.L. Ziober et al., "Expression of the alpha 7 beta 1 laminin receptor suppresses melanoma growth and metastatic potential", CELL GROWTH, 10(7), 1999, pp. 479-490

Abstract

The alpha 7 beta 1 integrin is a laminin-binding receptor that was originally identified in melanoma, Here, we show that, in clonally derived mouse K1735 melanoma variant cell lines with high (M-2) and low (C-23) metastatic potential, elevated expression of alpha 7 correlates with reduced cell motility, metastasis, and tumor growth. Both cell lines showed similar beta 1 integrin-dependent adhesion to laminin-1 and the E8 laminin fragment. However, the highly metastatic M-2 cells rapidly migrated on laminin, whereas thenonmetastatic C-23 cells were minimally motile, Laminin-binding integrin profiles showed that the M-2 cells expressed moderate amounts of alpha 1 andabundant alpha 6 but low or undetectable levels of alpha 2 and alpha 7, Bycontrast, C-23 cells expressed low or undetectable levels of alpha 1, alpha 2, and alpha 6 but had up-regulated levels of alpha 7, Consistent with the protein data, Northern blot analysis showed that levels of alpha 7 mRNA were highest in the poorly metastatic variant cells, whereas alpha 6 messagewas not detected; in contrast, alpha 6 mRNA was elevated in the highly metastatic cells, whereas alpha 7 message was not detected. Forced expression of alpha 7 in the M-2 cells suppressed cell motility, tumor growth, and metastasis. Collectively, these results indicate that, during melanoma progression, acquisition of a highly tumorigenic and metastatic melanoma phenotypeis associated with loss of the alpha 7 beta 1 laminin receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:59:35