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Titolo:
Observations of prostate specific antigen doubling time in Japanese patients with nonmetastatic prostate carcinoma
Autore:
Egawa, S; Matsumoto, K; Suyama, K; Iwamura, M; Kuwao, S; Baba, S;
Indirizzi:
Kitasato Univ, Sch Med, Dept Urol, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ Sagamihara Kanagawa Japan 2288555 , Kanagawa 2288555, Japan Kitasato Univ, Dept Pathol, Sch Med, Sagamihara, Kanagawa 228, Japan Kitasato Univ Sagamihara Kanagawa Japan 228 gamihara, Kanagawa 228, Japan
Titolo Testata:
CANCER
fascicolo: 3, volume: 86, anno: 1999,
pagine: 463 - 469
SICI:
0008-543X(19990801)86:3<463:OOPSAD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER; MEN; PROGRESSION; BEHAVIOR; DISEASE; VOLUME; RISK;
Keywords:
prostate carcinoma; prostate specific antigen; watchful waiting; racial difference; natural history; prostate specific antigen doubling time; clinical significance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Egawa, S Kitasato Univ, Sch Med, Dept Urol, 1-15-1 Kitasato, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ 1-15-1 Kitasato Sagamihara Kanagawa Japan 2288555 n
Citazione:
S. Egawa et al., "Observations of prostate specific antigen doubling time in Japanese patients with nonmetastatic prostate carcinoma", CANCER, 86(3), 1999, pp. 463-469

Abstract

BACKGROUND. To understand better the natural history and biology of prostate carcinoma occurring in Japanese patients, the authors attempted to define changes with time in prostate specific antigen (PSA) measurements in 48 men with clinically resectable T1-T3 nonmetastatic disease. METHODS. The authors analyzed PSA changes prospectively in prostate carcinoma patients who were managed by watchful waiting. PSA doubling time was calculated by linear regression. These values and their distribution were compared with clinical parameters and with published series of prostate carcinoma patients. RESULTS. The mean age of the 48 patients at the time of diagnosis was 74.2years. The median follow-up from the time of diagnosis was 24.0 months. The median PSA doubling time was 35.7 months. In 27.1% of patients, there wasno increase in the PSA level over the observation period. A rapid rise in PSA (doubling time of <2 years) was observed in 29.2% of patients. These results in Japanese patients are virtually the same as those reported in Western countries. There was no statistically significant relation between calculated PSA doubling time and clinical disease stage, tumor grade, PSA levelat the time of diagnosis, probability of extraprostatic disease, patient age at diagnosis, or prostate volume (P > 0.05). CONCLUSIONS. Prostate carcinoma may not differ significantly by race once it becomes clinically manifest. The magnitude of positive changes in PSA over a given period of observation may not be helpful in determining the needfor therapy. The previously reported incidence of clinically insignificantprostate carcinoma, which primarily was based on pathologic findings in surgical specimens, may have been an underestimation. (C) 1999 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:41:38