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Titolo:
Thermomechanical analysis of collagen crosslinking in the developing ovinethoracic aorta
Autore:
Wells, SM; Adamson, SL; Langille, BL; Lee, JM;
Indirizzi:
Dalhousie Univ, Sch Biomed Engn, Halifax, NS B3H 3J5, Canada Dalhousie Univ Halifax NS Canada B3H 3J5 ngn, Halifax, NS B3H 3J5, Canada Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Obstet & Gynecol,Inst Biomat & Biomed Engn, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 Engn, Toronto, ON M5G 1X5, Canada Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Lab Med, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 b Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Pathobiol, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 obiol, Toronto, ON M5G 1X5, Canada
Titolo Testata:
BIORHEOLOGY
fascicolo: 6, volume: 35, anno: 1998,
pagine: 399 - 414
SICI:
0006-355X(199811/12)35:6<399:TAOCCI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; HEAT-INDUCED CHANGES; THERMAL-STABILITY; CROSS-LINKING; RAT SKIN; TISSUE; SHRINKAGE; TENSION; ORGANIZATION; MATURATION;
Keywords:
collagen; crosslinking; development; hydrothermal isometric tension tests; denaturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JM Dalhousie Univ, Sch Biomed Engn, 5981 Univ Ave, Halifax, NS B3H 3J5, Canada Dalhousie Univ 5981 Univ Ave Halifax NS Canada B3H 3J5 3J5, Canada
Citazione:
S.M. Wells et al., "Thermomechanical analysis of collagen crosslinking in the developing ovinethoracic aorta", BIORHEOLOGY, 35(6), 1998, pp. 399-414

Abstract

We have used hydrothermal isometric tension (HIT) techniques in a sheep model to assess collagen crosslink stability and its contribution to the mechanical properties of the ovine thoracic aorta during perinatal and postnatal development. Aortic tissue was studied from fetal sheep, Iambs, and adultsheep. Strips of tissue were loaded under isometric tension and heated to a 90 degrees C isotherm which was sustained for 3 hours. The decrease in load at this temperature is associated with collagen peptide bond hydrolysis and chain slippage, and the rate of this decrease is an inverse indicator of collagen crosslinking. The half-time of load decay (t(1/2)) was computed before and after tissue was treated with NaBH4 which stabilizes immature, reducible crosslinks. We observed a two-fold increase in tilt of untreated tissue from the lamb to the adult, indicating that aortic collagen crosslinking increased during postnatal development. Furthermore, the t(1/2) of NaBH4-stabilized lamb tissue was similar to that of the untreated adult tissue,suggesting that much of the immature crosslinking in the lamb is stabilized during postnatal development. These observations suggest (a) increased crosslinking occurs during postnatal development and (b) that this increase is largely due to a conversion of immature crosslinks into their mature, heat stable form.

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Documento generato il 10/04/20 alle ore 16:02:15