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Titolo:
Brain noradrenergic responses to footshock after chronic activity-wheel running
Autore:
Soares, J; Holmes, PV; Renner, KJ; Edwards, GL; Bunnell, BN; Dishman, RK;
Indirizzi:
Univ Georgia, Dept Exercise Sci, Ramsey Student Ctr, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Ramsey Student Ctr, Athens, GA 30602 USA Univ Georgia, Dept Psychol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 rgia, Dept Psychol, Athens, GA 30602 USA Univ S Dakota, Dept Biol, Vermillion, SD 57069 USA Univ S Dakota Vermillion SD USA 57069 Dept Biol, Vermillion, SD 57069 USA Univ Georgia, Dept Physiol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 rgia, Dept Physiol, Athens, GA 30602 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 3, volume: 113, anno: 1999,
pagine: 558 - 566
SICI:
0735-7044(199906)113:3<558:BNRTFA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; MEDIAL FRONTAL-CORTEX; RAT LOCUS-COERULEUS; NORADRENALINE RELEASE; TREADMILL EXERCISE; INTRACRANIAL MICRODIALYSIS; NOREPINEPHRINE RELEASE; TYROSINE-HYDROXYLASE; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Dishman, RK Univ Georgia, Dept Exercise Sci, Ramsey Student Ctr, 300 RiverRd, Athens,GA 30602 USA Univ Georgia 300 River Rd Athens GA USA 30602 ens,GA 30602 USA
Citazione:
J. Soares et al., "Brain noradrenergic responses to footshock after chronic activity-wheel running", BEHAV NEURO, 113(3), 1999, pp. 558-566

Abstract

Effects of physical activity on brain noradrenergic response to footshock were examined. Male Fischer 344 rats were randomly assigned to shoebox cages with (AW) or without (SED) 24-hr access to an activity wheel for 4-5 weeks. Extracellular levels of norepinephrine (NE) and 3,4-dihydroxyphenyl-acetic acid (DOPAC) in the brain frontal cortex were measured in 20-min samplesof microdialysate taken during a 2-hr baseline, 40 min of scrambled footshock, and a 1-hr recovery. Levels of messenger RNA (mRNA) for tyrosine hydroxylase (TH), c-fos, and prepro-galanin in the locus coeruleus were measuredby in situ hybridization histochemistry with autoradiographic analysis. NElevels were the same for SED and AW rats at baseline but were elevated in SED compared with AW during and after footshock. Levels of mRNA for TH and c-fos were elevated after footshock but did not differ between SED and AW. Our findings suggest that wheel running blunts NE release in the brain frontal cortex in response to footshock but does not influence expression of the gene that encodes TH in the locus coeruleus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:31:22