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Titolo:
Inhibition of Borna disease virus multiplication by interferon: cell line differences in susceptibility
Autore:
Hallensleben, W; Staeheli, P;
Indirizzi:
Univ Freiburg, Inst Med Mikrobiol & Hyg, Dept Virol, D-79008 Freiburg, Germany Univ Freiburg Freiburg Germany D-79008 Virol, D-79008 Freiburg, Germany
Titolo Testata:
ARCHIVES OF VIROLOGY
fascicolo: 6, volume: 144, anno: 1999,
pagine: 1209 - 1216
SICI:
0304-8608(1999)144:6<1209:IOBDVM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENTLY INFECTED-CELLS; IN-VITRO; AMANTADINE; RATS; REPLICATION; ANIMALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Staeheli, P Univ Freiburg, Inst Med Mikrobiol & Hyg, Dept Virol, Hermann Herder Str 11, D-79008 Freiburg, Germany Univ Freiburg Hermann Herder Str 11Freiburg Germany D-79008
Citazione:
W. Hallensleben e P. Staeheli, "Inhibition of Borna disease virus multiplication by interferon: cell line differences in susceptibility", ARCH VIROL, 144(6), 1999, pp. 1209-1216

Abstract

It has previously been reported that de novo infection of primary rabbit brain cells with Borna disease virus (BDV) can be blocked with interferon-alpha/beta (IFN), whereas this cytokine has no inhibitory effect on BDV in persistently infected rat lung cells [v. Rheinbaben et al., J. Gen. Virol. (1985) 66: 2777-2780]. It remained unclear, however, whether these results indicated that IFN exclusively targets early steps of the BDV replication cycle or whether they simply reflected cell line differences. We now show thatBDV replication was effectively inhibited by IFN in both acutely and persistently infected monkey Vero cells. By contrast, IFN had no clear protective effect on either de novo or persistent BDV infections of rat C6 glioblastoma cells. IFN protected C6 cells from the cytopathic effects of vesicular stomatitis virus, excluding the possibility that these cells are devoid of a functional IFN system. In primary rat fibroblasts and in a human oligodendroglial cell line, IFN induced an efficient antiviral state against BDV. These results indicate that BDV is highly susceptible to the antiviral effect of IFN in some cell lines, while others seem to lack undefined componentsof the IFN system which mediate protection against BDV.

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Documento generato il 27/01/20 alle ore 07:33:01