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Titolo:
Angiogenesis in the bovine corpus luteum: An immunocytochemical and ultrastructural study
Autore:
Amselgruber, WM; Schafer, M; Sinowatz, F;
Indirizzi:
Univ Hohenheim, Inst Anat & Physiol, D-70593 Stuttgart, Germany Univ Hohenheim Stuttgart Germany D-70593 iol, D-70593 Stuttgart, Germany Univ Munich, Inst Vet Anat 2, Munich, Germany Univ Munich Munich Germany niv Munich, Inst Vet Anat 2, Munich, Germany
Titolo Testata:
Anatomia, histologia, embryologia
fascicolo: 3, volume: 28, anno: 1999,
pagine: 157 - 166
SICI:
0340-2096(199907)28:3<157:AITBCL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELL GROWTH; LYMPHOCYTE-INDUCED ANGIOGENESIS; TUMOR-RELATED ANGIOGENESIS; CAPILLARY-LIKE STRUCTURES; SMOOTH-MUSCLE CELLS; EXTRACELLULAR-MATRIX; GRANULATION-TISSUE; INVITRO; NEOVASCULARIZATION; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Amselgruber, WM Univ Hohenheim, Inst Anat & Physiol, Fruwirthstr 35, D-70593 Stuttgart, Germany Univ Hohenheim Fruwirthstr 35 Stuttgart Germany D-70593 y
Citazione:
W.M. Amselgruber et al., "Angiogenesis in the bovine corpus luteum: An immunocytochemical and ultrastructural study", ANAT HISTOL, 28(3), 1999, pp. 157-166

Abstract

Immediately after ovulation a neovascular response occurs at the level of the theca interna. Pericytes and endothelial cells of post-capillary venules locally remodel the surrounding stroma, elongate and migrate into the avascular granulosa folds of the ruptured follicle. In order to examine the composition of the extracellular matrix as well as the growth characteristicsof these newly formed vessels, we used immunohistochemical and electron microscopic methods. Initial sprouts were characterized by the appearance of a fibrillary network of fibronectin along the main axis of the sprout. TypeIV collagen stained weakly and extracellular deposits of laminin were amorphous and patchy around immature capillary sprouts. In advanced maturational stages of the sprouts the capillaries were surrounded by increased deposits of fibronectin, whereas laminin and type IV collagen displayed a distinct and well-developed line around endothelial cells and pericytes. These observations indicate that the microvascular extracellular matrix undergoes a series of quantitative rather than qualitative changes during capillary development before achieving final maturation. Ultrastructural analyses showedthat early capillary sprouts in the bovine corpus luteum were usually preceded by pericytes migrating at the tips of the sprouts. Endothelial cells comigrated in cohesive cylindrical projections, forming immediately a slit-like lumen which satisfies the criteria of the intercellular canalization type. Pericytes at the tips of endothelial sprouts exhibited a slender, bipolar morphology and were regularly surrounded by fragmented basal lamina, which is well-developed around pericytes in a more proximal position of the sprout. The regular association of pericytes with the leading front of the capillary sprouts suggests that these cell types may serve as guiding structures aiding outgrowth of endothelial cells in the bovine corpus luteum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:54:16