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Titolo:
Trend for an association between schizophrenia and D3S1310, a marker in proximity to the dopamine D3 receptor gene
Autore:
Jonsson, EG; Nimgaonkar, VL; Zhang, XR; Shaw, SH; Burgert, E; Crocq, MA; Chakravarti, A; Sedvall, GC;
Indirizzi:
Karolinska Hosp, Psychol Sect, Dept Clin Neurosci, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 ci, SE-17176 Stockholm, Sweden Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Human Genet, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 n Genet, Pittsburgh, PA 15213 USA Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Freiburg, Inst Human Genet, Freiburg, Germany Univ Freiburg Freiburg Germany urg, Inst Human Genet, Freiburg, Germany Ctr Hosp, Rouffach, France Ctr Hosp Rouffach FranceCtr Hosp, Rouffach, France
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 4, volume: 88, anno: 1999,
pagine: 352 - 357
SICI:
0148-7299(19990820)88:4<352:TFAABS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE ANALYSIS; NO ASSOCIATION; FAMILY HISTORY; DRD3 GENE; POLYMORPHISM; HOMOZYGOSITY; LOCUS; ALLELES; D2; HETEROGENEITY;
Keywords:
schizophrenia; genetics; association; dopamine D-3 receptor gene locus; dopamine receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Jonsson, EG Karolinska Hosp, Psychol Sect, Dept Clin Neurosci, SE-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden SE-17176 Stockholm, Sweden
Citazione:
E.G. Jonsson et al., "Trend for an association between schizophrenia and D3S1310, a marker in proximity to the dopamine D3 receptor gene", AM J MED G, 88(4), 1999, pp. 352-357

Abstract

There is considerable controversy regarding a putative association betweenschizophrenia and a biallelic BalI polymorphism in the first exon of the dopamine D3 receptor gene (DRD3), although meta-analyses of published data suggest an association. If such an association exists, it may be detectable at markers physically close to DRD3. Accordingly,we conducted a case-control association study using D3S1310, a short tandem repeal polymorphism-located approximately 700 kb;telomeric to DRD3 on chromosome 3q13.3. The subjects were Swedish patients with schizophrenia (DSM III-R criteria, n = 110) and screened adult controls (n = 83). A trend for a negative association withthe 141 bp allele was detected (chi(2) = 7.6, d.f. = 1, P = 0.006; odds ratio 0.46, 95% confidence intervals 0.26, 0.81), However, following corrections for multiple comparisons using subgroups (n = 15) the difference was not significant. Also, due to the risk for population stratification in case-control association studies the results must be treated as tentative. If replicated the results may lend further support for the proposition of an association between schizophrenia and DRD3 or a gene in close proximity to DRD3 on chromosome 3q, Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:352-357,1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 26/01/20 alle ore 01:22:31