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Titolo:
Older subjects show no age-related decrease in cardiac baroreceptor sensitivity
Autore:
Dawson, SL; Robinson, TG; Youde, JH; Martin, A; James, MA; Weston, PJ; Panerai, RB; Potter, JF;
Indirizzi:
Univ Leicester, Glenfield Gen Hosp, Dept Med Elderly, Leicester LE3 9QP, Leics, England Univ Leicester Leicester Leics England LE3 9QP er LE3 9QP, Leics, England Univ Leicester, Leicester Royal Infirm, Dept Med Phys, Leicester LE1 5WW, Leics, England Univ Leicester Leicester Leics England LE1 5WW er LE1 5WW, Leics, England
Titolo Testata:
AGE AND AGEING
fascicolo: 4, volume: 28, anno: 1999,
pagine: 347 - 353
SICI:
0002-0729(199907)28:4<347:OSSNAD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE VARIABILITY; RATE REFLEX SENSITIVITY; HEART-RATE-VARIABILITY; BAROREFLEX SENSITIVITY; VALSALVA MANEUVER; SPECTRAL-ANALYSIS; ARTERIAL BAROREFLEX; HUMANS; MODULATION; SEQUENCE;
Keywords:
age; blood pressure; cardiac baroreflex sensitivity; impulse response function; phase response; regression analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Dawson, SL Univ Leicester, Glenfield Gen Hosp, Dept Med Elderly, Groby Rd,Leicester LE3 9QP, Leics, England Univ Leicester Groby Rd Leicester Leics England LE3 9QP England
Citazione:
S.L. Dawson et al., "Older subjects show no age-related decrease in cardiac baroreceptor sensitivity", AGE AGEING, 28(4), 1999, pp. 347-353

Abstract

Objective: to examine the relationship between age, blood pressure and cardiac baroreceptor sensitivity derived from spectral analysis, the Valsalva manoeuvre and impulse response function. Methods: we studied 70 healthy normotensive volunteers who were free from disease and not taking medication with cardiovascular or autonomic effects. We measured beat-to-beat arterial. blood pressure and used standard surface electrocardiography to record pulse interval under standardized conditions with subjects resting supine as well as during three Valsalva manoeuvres. We performed single, multiple and stepwise regression of patient characteristics against cardiac baroreceptor sensitivity results. Results: there is a non-linear decline in cardiac baroreceptor sensitivitywith advancing age, increasing systolic blood pressure and heart rate values (except for the Valsalva-derived result), but little further decline after the fourth decade. Only age significantly influenced values derived using the Valsalva manoeuvre and impulse response analysis. Using spectral analysis, age, systolic and diastolic blood pressure and heart rate influenced cardiac baroreceptor sensitivity, age contributing to 50% of the variability. Age also influenced the relationship between pulse interval and blood pressure, possibly indicating more non-baroreceptor-mediated changes with advancing age. Conclusions: although age is the dominant factor influencing cardiac baroreceptor sensitivity in this normotensive population, there is little changein mean values after 40 years of age. The differences in the relationship between pulse interval and blood pressure with advancing age have implications for the calculation of cardiac baroreceptor sensitivity using spectral analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:35:18