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Titolo:
Serum levels of leukocyte functional antigen-3 in pregnancy and preeclampsia
Autore:
Hefler, L; Kainz, C; Zeisler, H; Heinze, G; Schatten, C; Husslein, P; Leodolter, S; Tempfer, C;
Indirizzi:
Univ Vienna, Sch Med, Dept Obstet & Gynecol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 stet & Gynecol, A-1090 Vienna, Austria Univ Vienna, Sch Med, Dept Med Comp Sci, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 t Med Comp Sci, A-1090 Vienna, Austria Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 tet & Gynecol, Houston, TX 77030 USA
Titolo Testata:
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
fascicolo: 7, volume: 78, anno: 1999,
pagine: 580 - 585
SICI:
0001-6349(199908)78:7<580:SLOLFA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; RECEPTOR CD58 LFA-3; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; SOLUBLE FORM; EXPRESSION; PHENOTYPE;
Keywords:
leukocyte functional antigen-3; preeclampsia; pregnancy; prognosis; serum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hefler, L Univ Vienna, Sch Med, Dept Obstet & Gynecol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 tria
Citazione:
L. Hefler et al., "Serum levels of leukocyte functional antigen-3 in pregnancy and preeclampsia", ACT OBST SC, 78(7), 1999, pp. 580-585

Abstract

Background. Adhesion molecules have been demonstrated to be involved in placental growth and development in normal pregnancy. Experimental evidence indicates that adhesion molecules are key factors of endothelial activation in preeclampsia. The aim of our study was to evaluate serum levels of the adhesion molecule Leukocyte Functional Antigen (LFA)-3 in healthy, non pregnant. female controls, healthy pregnant women, and preeclamptic women. Methods. In our study we included 45 healthy, non pregnant, female controls, 45 healthy pregnant women, and 45 preeclamptic women. An enzyme-linked immunosorbent: assay was used to determine serum levels of LFA-3. Results were correlated to clinical data. Results. The median LFA-3 serum level in healthy, non pregnant, female controls was 0.2 (rang 0 to 8.6) ng/mL. LFA-3 serum levels in healthy pregnantwomen were 4.8 (range 0 to 18) ng/mL and were significantly elevated compared to healthy, non pregnant, female controls (Mann-Whitney U-test, p=0.004). A cut-off level of 4.8 ng/mL was selected according to the 75th quantileof serum levels measured in the panel of healthy, non pregnant, female controls. In preeclamptic women, whose pregnancies had to be terminated due toexacerbation of preeclamptic symptoms, LFA-3 serum levels above the cut-off level were seen in 14/27 (52%) cases. In contrast, preeclamptic women, who went into spontaneous labor showed elevated LFA-3 serum levels in 17/18 (95%) cases (chi-square test, p=0.002). LFA-3 serum levels revealed a statistically significant influence on the odds of termination of pregnancy due to exacerbation of preeclamptic symptoms (unconditional logistic regression,p=0.02) with an odds ratio of 0.1 (95% Cl, 0.006 to 0.7) by every doublingof LFA-3 values. Conclusions. Our results suggest that LFA-3 expression is upregulated in healthy pregnant women compared to healthy, non pregnant, female controls. Failure of LFA-3 upregulation in preeclampsia is associated with an increased risk for termination of pregnancy due to exacerbation of preeclamptic symptoms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:02:34