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Titolo:
Experimental eye enlargement in mature animals changes the retinal pigmentepithelium
Autore:
Harman, AM; Hoskins, R; Beazley, LD;
Indirizzi:
Univ Western Australia, Dept Psychol, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 nds, WA 6907, Australia Univ Western Australia, Dept Zool, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 nds, WA 6907, Australia
Titolo Testata:
VISUAL NEUROSCIENCE
fascicolo: 4, volume: 16, anno: 1999,
pagine: 619 - 628
SICI:
0952-5238(199907/08)16:4<619:EEEIMA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SETONIX-BRACHYURUS; EXPERIMENTAL MYOPIA; DEPRIVATION MYOPIA; AREA CENTRALIS; GROWTH; TOPOGRAPHY; CHICKENS; QUOKKA; CELL; CAT;
Keywords:
myopia; marsupial; occlusion; retina;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Harman, AM Univ Western Australia, Dept Psychol, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 7, Australia
Citazione:
A.M. Harman et al., "Experimental eye enlargement in mature animals changes the retinal pigmentepithelium", VIS NEUROSC, 16(4), 1999, pp. 619-628

Abstract

Form deprivation has been shown to result in myopia in a number of speciessuch that the eye enlarges if one eye is permanently closed at the time ofeye opening. In the quokka wallaby, the eye grows slowly throughout life. After form deprivation, the eye enlarges by 1-1.5 years of age to the size of that in a 4-6-year-old animal and the number of multinucleated retinal pigment epithelial (RPE) cells in the enlarged retina remains much lower than would be expected in eyes of comparable size. Here we have repeated the experiment but examined animals at 4 years of age. The sutured eye grew significantly larger than did its partner. Numbers of RPE cells were comparablebetween sutured and partner eyes but were lower than in normal animals of similar age. Reductions in RPE cell density were greater in nasal than in dorsal or ventral retina and were not seen in temporal retina. The distribution of multinucleated cells was quite different in the sutured and open eyes. As in normal eyes, partner eyes had most multinucleated cells in ventralretina, while in the sutured eyes such cells were located mainly in the far periphery. In conclusion, the RPE is significantly changed by the eye enlargement process. However, it is not known whether this change results froman active part played by the RPE in the retinal expansion process or whether the changes are simply a result of a passive increase in area of the RPE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 03:49:15