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Titolo:
Feasibility of a rapid dipstick antigen-capture assay for self-testing of travellers' malaria
Autore:
Trachsler, M; Schlagenhauf, P; Steffen, R;
Indirizzi:
Univ Zurich, Inst Social & Prevent Med, Div Communicable Dis, Travel Clin,CH-8006 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8006 Clin,CH-8006 Zurich, Switzerland
Titolo Testata:
TROPICAL MEDICINE & INTERNATIONAL HEALTH
fascicolo: 6, volume: 4, anno: 1999,
pagine: 442 - 447
SICI:
1360-2276(199906)4:6<442:FOARDA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM INFECTION; DIAGNOSIS; TRAVELERS;
Keywords:
antigen-capture assay; malaria; self-test; travellers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Trachsler, M Univ Zurich, Inst Social & Prevent Med, Div Communicable Dis,Travel Clin,Sumatrastr 30, CH-8006 Zurich, Switzerland Univ Zurich Sumatrastr 30 Zurich Switzerland CH-8006 zerland
Citazione:
M. Trachsler et al., "Feasibility of a rapid dipstick antigen-capture assay for self-testing of travellers' malaria", TR MED I H, 4(6), 1999, pp. 442-447

Abstract

This open comparative study sought to determine whether, and with what level of instruction, travellers san successfully use and interpret the rapid whole blood malaria diagnostic test, ParaSight F. 160 visitors to the Zurich University Travel Clinic took part in the study. One group received written instructions only, while another group was given combined oral and written instructions on how to tot their own blood for malaria infection and interpret a series of 5 prepared test strips. Each volunteer also completed a questionnaire targeted at assessing performance in using the diagnostic, interpretation of the results and acceptability of the concept of self-testing. for malaria infection. The main outcome measures were successful performance of the rest, correct interpretation. of prepared test strips and acceptability of the rest. In the group which received only written instructions. 60/80 (75%) were successful, whilst in the group which received written and oral instructions, 72/80 (90%) successfully performed the test (P < 0.02). Overall, 56S (70.6%) test strips were correctly and 165 (20.6%) incorrectly interpreted with 113 (14.1%) false negative interpretations. No prepared test strip was interpreted as false positive. Seventy (8.8%) test strips were not interpreted, Some 91.9% of all candidates would use such a test ifit were available. While it is possible for lay persons to successfully perform the rest, interpretation of results poses a problem. In particular, the proportion of false negative interpretations is unacceptable. A combination of written and oral instructions leads to 3 significantly higher level of successful test performance. If such a rest is to be made available to the general public, written instructions must be made concise and foolproof and the test endpoint clearly defined, as the currently available test is more suitable for trained laboratory personnel. In the meantime oilier candidate diagnostics have become available and these should now be assessed fortheir suitability in the context of travellers' malaria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:59:16