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Titolo:
Acetylcholine in mind: a neurotransmitter correlate of consciousness?
Autore:
Perry, E; Walker, M; Grace, J; Perry, R;
Indirizzi:
Newcastle Gen Hosp, MRC, Neurochem Pathol Unit, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Newcastle Upon Tyne Tyne & WearEngland NE4 6BE ngland Newcastle Gen Hosp, Dept Old Age Psychiat, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE ngland Newcastle Gen Hosp, Dept Neuropathol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE ngland
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 6, volume: 22, anno: 1999,
pagine: 273 - 280
SICI:
0166-2236(199906)22:6<273:AIMANC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEP BEHAVIOR DISORDER; LEWY-BODY DISEASE; NUCLEUS BASALIS MAGNOCELLULARIS; PROBABLE ALZHEIMERS-DISEASE; EVENT-RELATED POTENTIALS; PLACEBO-CONTROLLED TRIAL; REM-SLEEP; PARKINSONS-DISEASE; DOUBLE-BLIND; COGNITIVE FUNCTIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Perry, E Newcastle Gen Hosp, MRC, Neurochem Pathol Unit, Westgate Rd, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Westgate Rd Newcastle Upon Tyne Tyne & Wear England NE4 6BE
Citazione:
E. Perry et al., "Acetylcholine in mind: a neurotransmitter correlate of consciousness?", TRENDS NEUR, 22(6), 1999, pp. 273-280

Abstract

The cholinergic system is one of the most important modulatory neurotransmitter systems in the brain and controls activities that depend on selectiveattention, which are an essential component of conscious awareness. Psychopharmacological and pathological evidence supports the concept of a 'cholinergic component' of conscious awareness. Drugs that antagonize muscarinic receptors induce hallucinations and reduce the level of consciousness, whilethe nicotinic receptor is implicated as being involved in the mechanism ofaction of general (inhalational) anaesthetics. In degenerative diseases ofthe brain, alterations in consciousness are associated with regional deficits in the cholinergic system. In Alzheimer's disease (AD), there is a lossof explicit (more than implicit) memory and hypoactivity of cholinergic projections to the hippocampus and cortex, while the visual hallucinations experienced by subjects with Dementia with Lewy bodies (DLB) are associated with reductions in neocortical ACh-related activity, In Parkinson's disease,the additional loss of pedunculopontine cholinergic neurones, which control REM (rapid eye movement) sleep or dreaming, is likely to contribute to REM abnormalities, which also occur in DLB, Widespread basal-forebrain and rostral brainstem cholinergic pathways, which include converging projections to the thalamus, appear to be located strategically for generating and integrating conscious awareness. Alleviation of a range of cognitive and non-cognitive symptoms by drugs that modulate the cholinergic system, which are being developed for the treatment of AD and related disorders, could be caused by changes in consciousness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:59:13