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Titolo:
Regional cerebral blood flow abnormalities in chronic solvent abusers
Autore:
Okada, SI; Yamanouchi, N; Kodama, K; Uchida, Y; Hirai, S; Sakamoto, T; Noda, S; Komatsu, N; Sato, T;
Indirizzi:
Chiba Univ, Sch Med, Dept Neuropsychiat, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 ropsychiat, Chuo Ku, Chiba 2608670, Japan Chiba Univ Hosp, Dept Radiol, Chiba, Japan Chiba Univ Hosp Chiba JapanChiba Univ Hosp, Dept Radiol, Chiba, Japan Chiba Municipal Hosp, Dept Psychiat, Chiba, Japan Chiba Municipal Hosp Chiba Japan ipal Hosp, Dept Psychiat, Chiba, Japan Natl Psychiat Inst Shimofusa, Dept Psychiat, Chiba, Japan Natl Psychiat Inst Shimofusa Chiba Japan a, Dept Psychiat, Chiba, Japan
Titolo Testata:
PSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 3, volume: 53, anno: 1999,
pagine: 351 - 356
SICI:
1323-1316(199906)53:3<351:RCBFAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER CHANGES; TOLUENE ABUSE; ENCEPHALOPATHY;
Keywords:
amotivational syndrome; regional cerebral blood flow; Scale for the Assessment of Negative Symptoms; single photon emission computed tomography; solvent abuse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, SI Chiba Univ, Sch Med, Dept Neuropsychiat, Chuo Ku, 1-8-1 Inohana,Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 iba 2608670, Japan
Citazione:
S.I. Okada et al., "Regional cerebral blood flow abnormalities in chronic solvent abusers", PSY CLIN N, 53(3), 1999, pp. 351-356

Abstract

This study aimed to reveal regional abnormalities of cerebral blood flow (CBF) and their relation to amotivational syndrome which causes poor social prognosis in solvent abusers. Sixteen chronic solvent abusers (12 males andfour females) along with five normal subjects underwent single photon emission computed tomography with N-isopropyl-p[I-123] iodoamphetamine. The patients received a clinical evaluation with the Scale for the Assessment of Negative Symptoms. Using a semiquantitative method (normalized by the parietal cortex count), patients showed a statistically significant decrease in regional cerebral blood flow (rCBF) in the bilateral prefrontal cortices (P < 0.01). In addition, the severity of hypoperfusion in the bilateral prefrontal cortices was related to the degree of severity of the avolition-apathyscale on SANS (left; P < 0.05, right; P < 0.01) even after excluding the effect of antipsychotics, These results suggest that rCBF abnormalities, especially in the prefrontal cortex, develop in chronic solvent abusers, and that this frontal hypoperfusion may be a biological basis of amotivational syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:57:17