Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Stress-induced behaviors require the corticotropin-releasing hormone (CRH)receptor, but not CRH
Autore:
Weninger, SC; Dunn, AJ; Muglia, LJ; Dikkes, P; Miczek, KA; Swiergiel, AH; Berridge, CW; Majzoub, JA;
Indirizzi:
Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 , Div Endocrinol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Childrens Hosp, Howard Hughes Med Inst, Program Neurosci, Boston, MA 02115USA Childrens Hosp Boston MA USA 02115 Program Neurosci, Boston, MA 02115USA Childrens Hosp, Dept Neurol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Neurol, Boston, MA 02115 USA Louisiana State Univ, Med Ctr, Dept Pharmacol, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ol, Shreveport, LA 71130 USA Tufts Univ, Dept Psychol, Medford, MA 02155 USA Tufts Univ Medford MA USA02155 Univ, Dept Psychol, Medford, MA 02155 USA Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Psychol, Madison, WI 53706 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 14, volume: 96, anno: 1999,
pagine: 8283 - 8288
SICI:
0027-8424(19990706)96:14<8283:SBRTCH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EDINGER-WESTPHAL NUCLEUS; UROCORTIN-LIKE IMMUNOREACTIVITY; CENTRAL-NERVOUS-SYSTEM; RAT-BRAIN; MESSENGER-RNA; IN-VIVO; ANTAGONIST; ANXIETY; MICE; NEUROPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Majzoub, JA Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA ChildrensHosp Boston MA USA 02115 inol, Boston, MA 02115 USA
Citazione:
S.C. Weninger et al., "Stress-induced behaviors require the corticotropin-releasing hormone (CRH)receptor, but not CRH", P NAS US, 96(14), 1999, pp. 8283-8288

Abstract

Corticotropin-releasing hormone (CRH) is a central regulator of the hormonal stress response, causing stimulation of corticotropin and glucocorticoidsecretion. CRH is also widely believed to mediate stress-induced behaviors, implying a broader, integrative role for the hormone in the psychologicalstress response. Mice lacking the CRH gene exhibit normal stress-induced behavior that is specifically blocked by a CRH type 1 receptor antagonist. The other known mammalian ligand for CRH receptors is urocortin, Normal and CRH-deficient mice have an identical distribution of urocortin mRNA, which is confined to the region of the Edinger-Westphal nucleus, and is absent from regions known to mediate stress-related behaviors. Since the Edinger-Westphal nucleus is not known to project to any brain regions believed to playa role in anxiety-like behavior, an entirely different pathway must be postulated for urocortin in the Edinger-Westphal nucleus to mediate these behaviors in CRH-deficient mice. Alternatively, an unidentified CRH-like molecule other than CRH or urocortin, acting through the CRH receptors in brain regions believed to mediate stress-induced behaviors, may mediate the behavioral response to stress, either alone or in concert with CRH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:11:12