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Titolo:
Atypical antipsychotics in older adults
Autore:
Chan, YC; Pariser, SF; Neufeld, G;
Indirizzi:
Ohio State Univ, Dept Psychiat, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 pt Psychiat, Columbus, OH 43210 USA Ohio State Univ, Dept Obstet & Gynecol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 t & Gynecol, Columbus, OH 43210 USA
Titolo Testata:
PHARMACOTHERAPY
fascicolo: 7, volume: 19, anno: 1999,
pagine: 811 - 822
SICI:
0277-0008(199907)19:7<811:AAIOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE-ONSET SCHIZOPHRENIA; BLIND OLANZAPINE TRIAL; LATE-LIFE; PARKINSONS-DISEASE; BIPOLAR DISORDER; INDUCED AGRANULOCYTOSIS; EXTRAPYRAMIDAL SIGNS; PSYCHOTIC DEPRESSION; ALZHEIMERS-DISEASE; GERIATRIC-PATIENTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, YC Ohio State Univ, Dept Psychiat, 1670 Upham Dr, Columbus, OH 43210USA Ohio State Univ 1670 Upham Dr Columbus OH USA 43210 OH 43210 USA
Citazione:
Y.C. Chan et al., "Atypical antipsychotics in older adults", PHARMACOTHE, 19(7), 1999, pp. 811-822

Abstract

Psychotic symptoms are common in older adults and reflect a variety of psychiatric and medical conditions. Antipsychotic drugs form the core of the treatment of these symptoms; however, treatment of the elderly is complicated by a high frequency of comorbid medical illnesses, risk of side effects, and age-related changes in pharmacodynamics and pharmacokinetics. The superior safety and efficacy of atypical antipsychotics makes them first-line agents for managing psychotic patients with schizophrenia. Their uses now extend to other conditions such as schizoaffective disorders, delusional disorder, and mood disorders with psychotic features. Although the drugs have been studied extensively in young subjects, well-designed, double-blind, placebo-controlled studies are relatively lacking in the elderly. Our knowledgeof their safety, efficacy and dosage in older adults is based on a few studies with small samples or extrapolated from studies of younger patients. Several psychiatric and medical conditions that are associated with psychotic symptoms in older people are reviewed, as well as how these patients may benefit from treatment with these agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:10:46