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Titolo:
Genetic aberrations detected by comparative genomic hybridization in biliary tract cancers
Autore:
Shiraishi, K; Kusano, N; Okita, S; Oga, A; Okita, K; Sasaki, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Pathol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Internal Med 1, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
ONCOLOGY
fascicolo: 1, volume: 57, anno: 1999,
pagine: 42 - 49
SICI:
0030-2414(1999)57:1<42:GADBCG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAS CODON-12 MUTATIONS; BREAST-CANCER; SOLID TUMORS; COPY NUMBER; CARCINOMA; AMPLIFICATION; GALLBLADDER; EXPRESSION; ADENOCARCINOMA; FREQUENT;
Keywords:
biliary tract cancers; comparative genomic hybridization; genetic aberrations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Shiraishi, K Yamaguchi Univ, Sch Med, Dept Pathol, 1144 Kogushi, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ 1144 Kogushi Ube Yamaguchi Japan 7558505 Japan
Citazione:
K. Shiraishi et al., "Genetic aberrations detected by comparative genomic hybridization in biliary tract cancers", ONCOL-BASEL, 57(1), 1999, pp. 42-49

Abstract

In order to elucidate cytogenetic changes characteristic of biliary tract cancer, we examined the genetic imbalances in 18 biliary tract cancers using comparative genomic hybridization (CGH). The most common sites of increases in copy number, in order of frequency, were 17q (33% of the cases), 5p (28%), 3q (22%), 7p (22%), 8q (22%), and 12p (22%), whereas copy number decreases of 6q (28%), 18q (28%), 4q (22%), 5q (22%), and 9p (22%) were frequent. The average number of chromosomal aberrations was significantly greater in stage IV than in stage III tumors (7.9 vs. 2.2/tumor, p < 0.05). The frequent aberrations detected in this study may be related to the development and/or progression of biliary tract cancers; This is the first report on CGH of biliary tract cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:47:13