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Titolo:
Correlation between increased cortisol : DHEA ratio and malnutrition in HIV-positive men
Autore:
Christeff, N; Melchior, JC; Mammes, O; Gherbi, N; Dalle, MT; Nunez, EA;
Indirizzi:
Hop Bichat, Lab Biochim B, F-75877 Paris 18, France Hop Bichat Paris France 18 chat, Lab Biochim B, F-75877 Paris 18, France Fac Med, Lab Biochim Endocrinienne & Biochim B, Paris, France Fac Med Paris France b Biochim Endocrinienne & Biochim B, Paris, France Hop Bichat, Serv Nutr, F-75877 Paris, France Hop Bichat Paris France F-75877 Bichat, Serv Nutr, F-75877 Paris, France
Titolo Testata:
NUTRITION
fascicolo: 7-8, volume: 15, anno: 1999,
pagine: 534 - 539
SICI:
0899-9007(199907/08)15:7-8<534:CBIC:D>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTING ENERGY-EXPENDITURE; VIRUS-INFECTED PATIENTS; BODY-COMPOSITION; SERUM; DEXAMETHASONE; ANDROGENS; AIDS;
Keywords:
body weight loss; malnutrition; cortisol; DHEA; cortisol : DHEA ratio; HIV-infected men;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Christeff, N Hop Bichat, Lab Biochim B, 46 Rue Henri Huchard, F-75877 Paris 18, France Hop Bichat 46 Rue Henri Huchard Paris France 18 s 18, France
Citazione:
N. Christeff et al., "Correlation between increased cortisol : DHEA ratio and malnutrition in HIV-positive men", NUTRITION, 15(7-8), 1999, pp. 534-539

Abstract

Malnutrition in HIV-infected patients is characterized by a loss of both fat-free mass (FFM) and fat mass (FM). Glucocorticoids and androgens change during the course of the infection and may play a key role in the protein balance. The serum concentrations of cortisol, adrenal (DHEA and DHEA sulfate) and gonadal androgens (androstenedione, testosterone, and dihydrotestosterone) of HIV-positive men were measured and compared with several parameters of body composition as a function of body weight loss (BWL). The patients were assigned to one of five groups according to their BWL: group I (controls, n = 10) <5%, group Il(n = 7) 5-10%, group III (n = 8) 10.1-16%, groupTV (n = 9) 16.1-24%, and group V (n = 4) >24.1%. Correlation analysis showed significant positive or negative relationships between several markers of malnutrition and adrenal androgens and the cortisol:DHEA ratio, but not with cortisol. BWL was negatively correlated with DHEA (I = -0.69, P < 0.0001), DHEA sulfate (r = -0.58, P < 0.0001) and testosterone (r = -0.34, P < 0.03), but positively with the cortisol:DHEA ratio (r = 0.61, P < 0.0001). In contrast, BCM was positively correlated with DHEA (r = 0.34, P < 0.04) and DHEA sulfate (r = 0.36, P < 0.03) and negatively with the cortisol:DHEA ratio (r = -0.58, P < 0.0001). The cortisol:DHEA ratio was also negatively correlated with BMT (body mass index) (r = -0.56, P < 0.01), fat-free mass (r = -0.48, P < 0.004), fat mass (r = -0.39, P < 0.02), and BCM:weight ratio(I = -0.47, P < 0.005) and positively with the extracellular:intracellularwater ratio (r = 0.54, P < 0.001). These data indicate that the steroid hormone environment of patients, particularly their cortisol:DHEA ratio, is linked to the malnutrition associated with HIV infection. The decreased DHEAand increased cortisol in patients with the advanced stages of disease could be associated with increased protein catabolism. (C) Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:11:31