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Titolo:
Telomerase activation and cell proliferation during 7,12-dimethylbenz[a]anthracene-induced hamster cheek pouch carcinogenesis
Autore:
Sumida, T; Hamakawa, H; Sogawa, K; Bao, Y; Zen, H; Sugita, A; Nezu, K; Abe, Y; Tanioka, H; Ueda, N;
Indirizzi:
Ehime Univ, Sch Med, Dept Oral Surg, Shigenobu, Ehime 7910295, Japan EhimeUniv Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Ehime Univ, Sch Med, Dept Pathol 1, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan
Titolo Testata:
MOLECULAR CARCINOGENESIS
fascicolo: 3, volume: 25, anno: 1999,
pagine: 164 - 168
SICI:
0899-1987(199907)25:3<164:TAACPD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN; CARCINOMAS; PROTEIN; LESIONS; CANCER;
Keywords:
flow-cytometric analysis; hamster; 7,12-dimethylbenz[a]anthracene; oral cancer; proliferating cell nuclear antigen; telomerase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sumida, T Ehime Univ, Sch Med, Dept Oral Surg, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 , Ehime 7910295, Japan
Citazione:
T. Sumida et al., "Telomerase activation and cell proliferation during 7,12-dimethylbenz[a]anthracene-induced hamster cheek pouch carcinogenesis", MOL CARCINO, 25(3), 1999, pp. 164-168

Abstract

Telomerase is a ribonucleoprotein complex intimately involved in cell immortalization and carcinogenesis. This enzyme is activated and stabilizes telomere length in almost all types of cancer. Telomerase may be necessary forcontinuous cell proliferation. In this study, we analyzed telomerase activity in hamster experimental oral lesions (starting from epithelial hyperplasia through dysplasia, carcinoma in situ, and invasive carcinoma) evoked by7,12-dimethylbenz[a]anthracene, and in normal mucosa. We also analyzed proliferative activity in these lesions by using immunohistochemical analysis and flow cytometry. Histologically normal epithelium expressed weak telomerase activity. The telomerase activity count increased rapidly in the early stage of carcinogenesis and gradually in the late stage. Cell-proliferativeactivity closely correlated with progression of disease. These findings indicate that telomerase activation is an early event and that increases in telomerase activity upregulate cell proliferation in chemically induced hamster oral carcinogenesis. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:12:04