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Titolo:
Fungemia during murine cryptococcosis sheds some light on pathophysiology
Autore:
Lortholary, O; Improvisi, L; Nicolas, M; Provost, F; Dupont, B; Dromer, F;
Indirizzi:
Inst Pasteur, Unite Mycol, F-75724 Paris 15, France Inst Pasteur Paris France 15 teur, Unite Mycol, F-75724 Paris 15, France
Titolo Testata:
MEDICAL MYCOLOGY
fascicolo: 3, volume: 37, anno: 1999,
pagine: 169 - 174
SICI:
1369-3786(199906)37:3<169:FDMCSS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; AMPHOTERICIN-B; MENINGITIS; NEOFORMANS; FLUCONAZOLE; AIDS; COMBINATION; FLUCYTOSINE; EFFICACY; INFECTIONS;
Keywords:
cryptococcosis; experimental model; fungemia; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Dromer, F Inst Pasteur, Unite Mycol, 25 Rue Dr Roux, F-75724 Paris 15, France Inst Pasteur 25 Rue Dr Roux Paris France 15 24 Paris 15, France
Citazione:
O. Lortholary et al., "Fungemia during murine cryptococcosis sheds some light on pathophysiology", MED MYCOL, 37(3), 1999, pp. 169-174

Abstract

We studied fungemia over time in outbred mice infected with Cryptococcus neoformans and looked at its relationship with the intravenous (i.v,) inoculum size, tissue burden and survival. Fungemia was evaluated by culture of 10 mu l of peripheral blood from living mice or by culture of buffy coats from sacrificed animals. For all inoculum sizes studied, fungemia could last several weeks after the i.v. inoculation. Individual susceptibility of outbred mice to cryptococcal infection was evidenced by variations in the course, duration and magnitude of fungemia and tissue localizations. These results suggest that the fungus can recirculate after the initial i.v. inoculation. Fungemia, assessed by culture of buffy coats, correlated with the extent of infection in the spleen, lung or brain (P < 0.001) on day I after inoculation but only with yeast burden in lung or spleen on day 8, thus demonstrating that brain reacts differently to C. neoformans infection than other organs. Comparison of blood culture techniques and examination of smears suggest that cryptococci might circulate within leucocytes. Finally, quantitative blood cultures may accurately assess the fungal load during experimental cryptococcosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:27:43