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Titolo:
In vivo imaging of extracellular pH using H-1 MRSI
Autore:
van Sluis, R; Bhujwalla, ZM; Raghunand, N; Ballesteros, P; Alvarez, J; Cerdan, S; Galons, JP; Gillies, RJ;
Indirizzi:
Univ Arizona, Ctr Hlth Sci, Dept Biochem & Radiol, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 t Biochem & Radiol, Tucson, AZ 85724 USA Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA Med, Dept Radiol, Baltimore, MD USA UNED, Dept Chem, Madrid, Spain UNED Madrid SpainUNED, Dept Chem, Madrid, Spain CSIC, IIB, Magnet Resonance Lab, Madrid, Spain CSIC Madrid SpainCSIC, IIB, Magnet Resonance Lab, Madrid, Spain
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 4, volume: 41, anno: 1999,
pagine: 743 - 750
SICI:
0740-3194(199904)41:4<743:IVIOEP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED-MAMMALIAN-CELLS; IN-VIVO; TUMORS; NMR; CLASTOGENICITY; SPECTROSCOPY; CANCER;
Keywords:
cancer; imidazole; MRSI; pH; tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Gillies, RJ Univ Arizona, Ctr Hlth Sci, Dept Biochem & Radiol, POB 245042,Tucson, AZ 85724 USA Univ Arizona POB 245042 Tucson AZ USA 85724 cson, AZ 85724 USA
Citazione:
R. van Sluis et al., "In vivo imaging of extracellular pH using H-1 MRSI", MAGN RES M, 41(4), 1999, pp. 743-750

Abstract

Tumor pH is physiologically important since it influences a number of processes relevant to tumorigenesis and therapy, Hence, knowledge of localized pH within tumors would contribute to understanding these processes. The destructiveness, poor spatial resolution, and poor signal-to-noise ratio (SNR)of current technologies (e.g., microelectrodes, P-31 magnetic resonance spectroscopy) have limited such studies. An extrinsic chemical extracellular pH (pH(e)) probe is described that is used in combination with H-1 magneticresonance spectroscopic imaging to yield pH(e) maps with a spatial resolution of 1 x 1 x 4 mm(3), The principle of the technique is demonstrated on aphantom, Further data are shown to demonstrate its application in vivo, and results agree with previously reported pH values. The accuracy of the reported pH measurements is <0.1 pH units, as derived from a detailed analysisof the errors associated with the technique, the description of which is included. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:20:28